ArticleTranslational cancer research2020
Incidence, treatment, and survival analysis in mediastinal malignant teratoma population.
Article in Translational cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 10 citations in OpenAlex.
- Cardiac tamponade and massive pleural effusion during pregnancy: a case of mediastinal malignant teratoma.Indian journal of thoracic and cardiovascular surgery · 2025Article
- Surgical outcomes in mediastinal mature teratoma.Indian journal of thoracic and cardiovascular surgery · 2025Article
- Robotic resection of mediastinal masses: a decade of experience.Journal of visualized surgery · 2024Article
- Posterior mediastinal teratoma presenting as an abdominal mass in a child: A case report.Radiology case reports · 2022Article
- [Mediastinal Teratoma: A Pictorial Essay].Taehan Yongsang Uihakhoe chi · 2022Article
- A radiomics model combined with XGBoost may improve the accuracy of distinguishing between mediastinal cysts and tumors: a multicenter validation analysis.Annals of translational medicine · 2021Article
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4 authors at 3 institutions in 1 country.
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Abstract
backgroundMediastinal malignant teratoma, as a germ cell tumor, is rare and lacking of population-based study. This study aims to illustrate the incidence, treatment and prognosis of mediastinal malignant teratoma by using a population-based database.
methodsWe gathered clinicopathological data (1975-2016) of malignant teratoma from the Surveillance, Epidemiology and End Results (SEER) database. Then we conducted analysis on the incidence, treatment and prognosis of mediastinal malignant teratoma and other malignant teratomas.
resultsA total of 5,550 cases were in our study cohort, including mediastinal malignant teratoma (n=133) and other malignant teratomas (n=5,417). The incidence of mediastinal malignant teratoma in 2016 was 0.004 per 100,000 persons. Both overall survival (OS) and cancer-specific survival (CSS) of mediastinal malignant teratoma were significantly worse than those of other malignant teratomas (both P<0.001). Surgery significantly improved OS and CSS of either early-staged or all-staged patients with mediastinal malignant teratoma (all P<0.001). However, both chemotherapy and radiotherapy negatively influenced both OS and CSS of patients with mediastinal malignant teratomas (all P<0.001). Besides, compared with surgery alone, combinational therapies like surgery + chemotherapy or surgery + radiotherapy were more harmful to OS and CSS (all P<0.001) of patients with mediastinal malignant teratoma.
conclusionsOur population-based evidence showed that mediastinal malignant teratoma, a rare cancer, had worse prognosis compared with other malignant teratomas. Compared with chemotherapy and radiotherapy, surgery could yield more survival benefits for either early-staged or all-staged patients with mediastinal malignant teratoma. Adjuvant use of chemotherapy/radiotherapy to surgery cannot improve but potentially harm patient prognosis.
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