Evidence map›Paper›PMID 35117592›Full record

ArticleTranslational cancer research2020

Screening key lncRNAs and mRNAs for left-sided and right-sided colon adenocarcinoma based on lncRNA-mRNA functional synergistic network.

Likun Yang, Junhong Ma, Lin Li, Shimin Yang, Changlin Zou, Xiangyang Yu

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 64% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Likun Yang *Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Junhong Ma *Department of Gastrointestinal Surgery, Nankai Clinical College of Tianjin Medical University, Tianjin 300100, China.
Lin LiDepartment of Gastrointestinal Surgery, Nankai Clinical College of Tianjin Medical University, Tianjin 300100, China.
Shimin YangDepartment of Gastrointestinal Surgery, Nankai Clinical College of Tianjin Medical University, Tianjin 300100, China.
Changlin ZouDepartment of Gastrointestinal Surgery, Nankai Clinical College of Tianjin Medical University, Tianjin 300100, China.
Xiangyang YuDepartment of Gastrointestinal Surgery, Nankai Clinical College of Tianjin Medical University, Tianjin 300100, China.
Tianjin Nankai Hospital · CNNankai University · CNTianjin University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe difference between right-sided colon adenocarcinoma (RSCOAD) and left-sided colon adenocarcinoma (LSCOAD) patients has been a controversial issue. The purpose of this study was to screen key lncRNAs and mRNAs in RSCOAD and LSCOAD.

methodsWe used The Cancer Genome Atlas (TCGA) data to screen differentially expressed lncRNAs (DElncRNAs) and mRNAs (DEmRNAs). The optimal diagnostic lncRNA biomarkers for RSCOAD and LSCOAD were identified using Boruta algorithm. DEmRNA-DElncRNA interaction analysis was constructed. DEmRNAs co-expressed with DElncRNAs were functionally annotated. The expression of selected DElncRNAs and DEmRNAs were verified by qRT-PCR.

resultsA total of 2,672 DEmRNAs (1,050 down-regulated and 1,622 up-regulated mRNAs) and 453 DElncRNAs (139 down-regulated and 314 up-regulated lncRNAs) between RSCOAD and LSCOAD were identified. We also obtained 31 optimal diagnostic lncRNAs biomarkers in RSCOAD compared to LSCOAD. The AUC of the random forests model was 0.902 and the specificity and sensitivity of this model were 83.5% and 82.1%, respectively. Three DElncRNAs (

conclusions

Indexed as

DElncRNAs-DEmRNAs co-expressiondifferentially expressed lncRNAs (DElncRNAs)differentially expressed mRNAs (DEmRNAs)left-sided colon adenocarcinoma (LSCOAD)Right-sided colon adenocarcinoma (RSCOAD)The Cancer Genome Atlas (TCGA)

Identifiers

PMID35117592
PMCPMC8798286
OpenAlexW3013846551

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.