Evidence map›Paper›PMID 35117582›Full record

ArticleTranslational cancer research2020

Progesterone receptor inhibits the proliferation and invasion of endometrial cancer cells by up regulating Krüppel-like factor 9.

Xiaofang Yan, Huilin Zhang, Jieqi Ke, Yongli Zhang, Chenyun Dai, Mei Zhu, Feizhou Jiang, Hongdi Zhu, Ling Zhang, Xin Zuo and 3 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 1 country.

Xiaofang Yan *Department of Obstetrics and Gynecology, Shanghai General Hospital of Nanjing Medical University, Shanghai 200000, China.
Huilin Zhang *Department of Obstetrics and Gynecology, Shanghai General Hospital of Nanjing Medical University, Shanghai 200000, China.
Jieqi KeDepartment of Obstetrics and Gynecology, Shanghai General Hospital of Nanjing Medical University, Shanghai 200000, China.
Yongli ZhangDepartment of Obstetrics and Gynecology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 200080, China.
Chenyun DaiDepartment of Translation Medicine, Shanghai First People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 210000, China.
Mei ZhuDepartment of Translation Medicine, Shanghai First People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 210000, China.
Feizhou JiangDepartment of Obstetrics and Gynecology, the First Affiliated Hospital of Soochow University, Suzhou 215000, China.
Hongdi ZhuDepartment of Gynecology and Obstetrics, Yixing People's Hospital, Yixing 214200, China.
Ling ZhangDepartment of Gynecology and Obstetrics, Yixing People's Hospital, Yixing 214200, China.
Xin ZuoDepartment of Gynecology and Obstetrics, Yixing People's Hospital, Yixing 214200, China.
Weiling LiDepartment of Gynecology and Obstetrics, Yixing People's Hospital, Yixing 214200, China.
Xiufeng YinDepartment of Gynecology and Obstetrics, Yixing People's Hospital, Yixing 214200, China.
Xiaoping WanDepartment of Obstetrics and Gynecology, Shanghai General Hospital of Nanjing Medical University, Shanghai 200000, China.
Yixing People's Hospital · CNJiangsu University · CNShanghai First People's Hospital · CNShanghai Jiao Tong University · CNFirst Affiliated Hospital of Soochow University · CNNanjing Medical University · CNShanghai First Maternity and Infant Hospital · CNShanghai Medical College of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundKrüppel-like factor 9 (KLF9) is one of the most important members of the KLF family, and is abnormally expressed in many tumors. However, the detailed function of KLF9 in endometrial cancer (EC) was barely investigated.

methodsIn this study, a total of 52 paired EC tissues were recruited to detect the KLF9 expression. Then a serial of phenotypic experiments and mechanism researches were performed.

resultsThe results showed that KLF9 expression was decreased in EC tissues, and the reduced expression of KLF9 is associated with highly metastatic capacity of EC cells. KLF9 could inhibit the proliferation and invasion of EC cells by inhibiting the Wnt/β-catenin signaling pathway. Progesterone receptor (PR) could bind to KLF9 promoter and a positive correlation between KLF9 and PR expression was witnessed.

conclusionsTaken together, the reduction of KLF9 induced by PR might participate in the development of EC and targeting KLF9 may provide a novel strategy for EC management.

Indexed as

Endometrial carcinomainvasionKrüppel-like factor 9 (KLF9)progesterone receptor (PR)proliferation

Identifiers

PMID35117582
PMCPMC8798504
OpenAlexW3015913087

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.