Evidence map›Paper›PMID 35117546›Full record

ReviewTranslational cancer research2020

The MDM2/MDMX/p53 axis in the adaptive stress response.

Bing Wang, Cody Rasmussen-Ivey, John B Little, Zhi-Min Yuan

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Translational cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Bing WangKey Laboratory of Space Radiobiology of Gansu Province & Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China.
Cody Rasmussen-IveyJohn B. Little Center for Radiation Sciences, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
John B LittleJohn B. Little Center for Radiation Sciences, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Zhi-Min YuanJohn B. Little Center for Radiation Sciences, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Institute of Modern Physics · CN

Funding

Training Program in Molecular and Integrative Physiological SciencesT32HL007118 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI LU, QUAN · 1985 to 2025
$14.3M
Modulation of p53 function by tyrosine kinase networksR01CA167814 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI YUAN, ZHI-MIN · 2012 to 2016
$1.6M
The role of beclin 1/class III PI-3 kinase and p53 in breast tumorigenesisR01CA125144 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI YUAN, ZHI-MIN · 2008 to 2012
$1.5M
Target MDM2/MDMX for reducing normal tissue toxicity induced by chemotherapyR01CA233558 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI YUAN, ZHI-MIN · 2019 to 2021
$1.1M
NCI NIH HHS R01 CA125144NCI NIH HHS R01 CA167814NCI NIH HHS R01 CA233558NHLBI NIH HHS T32 HL007118
6 · The paper itself

Abstract

Via regulation of cellular stress responses, p53 contributes to the maintenance of homeostasis. Contrary to its well-established pro-death function, p53 is also implicated in promoting cell survival by mediating the adaptive stress response. Emerging data reveal that the adaptive stress response is coupled with p53 decline that is a prerequisite for the induction of pro-survival pathways augmenting cell fitness. However, if the adaptive stress responses persist or become chronic, the sustained p53 downregulation would result in a permanent loss of p53 function and p53-dependent homeostasis. The available information suggests a model in which cells respond to different levels of stress by governing the activity and abundance of p53 that, in turn, determines the cell fate dependent on not only the intensity but also the duration of stress.

Indexed as

adaptive stress responsecell fatemild stressThe MDM2/MDMX/p53 axis

Identifiers

PMID35117546
PMCPMC8797865
OpenAlexW3009347162

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.