ArticleTranslational cancer research2020
Initial experience of drug-eluting bead transarterial chemoembolization with CalliSpheres
Article in Translational cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundTo evaluate the treatment efficacy, survival, safety profiles and factors affecting the clinical outcomes of drug-eluting bead transarterial chemoembolization (DEB-TACE) in liver metastases patients.
methodsA total of 39 liver metastases patients underwent DEB-TACE treatment with the novel CalliSpheres
resultsThe rate of complete response, partial response, stable disease and progressive disease of total treated cycles were 1.6%, 34.4%, 54.7% and 9.4%, respectively, and 5.0%, 26.7%, 57.8% and 10.6% of total treated nodules, respectively. Regarding survival, the median progression-free survival (PFS) was 15.3 months (95% CI: 9.7-20.8 months) and the median overall survival was 28.7 months (95% CI: 20.3-37.0 months). Cox's proportional hazard model regression analyses disclosed that previous liver resection was correlated with worse PFS, while combined targeted therapy and disease control rate after the first DEB-TACE were correlated with longer PFS. For safety profiles, biochemical indexes showed that patients' liver function was deteriorated at 1 week after DEB-TACE, but was mainly recovered at 1 month after DEB-TACE.
conclusionsDEB-TACE is an efficient and safe treatment choice for liver metastases, moreover, strict screening of indications for resection and combined therapy with targeted therapy might improve the efficacy of DEB-TACE.
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