ArticleTranslational cancer research2020
miR-378a-5p improved the prognosis and suppressed the progression of hepatocellular carcinoma by targeting the VEGF pathway.
Article in Translational cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- miR-378a-5p targets FGR to suppress proliferation, invasion and migration in lung adenocarcinoma cells.Translational cancer research · 2025Article
- miR-548ac and miR-378j as Potential Diagnostic Biomarkers in Gastric Cancer: A Case-Control Study.Middle East journal of digestive diseases · 2025Article
- Article
- MicroRNAs in Hepatocellular Carcinoma Pathogenesis: Insights into Mechanisms and Therapeutic Opportunities.International journal of molecular sciences · 2024Review
- A three miRNAs panel in paraffin tissue serves as tool for predicting prognosis of renal cell carcinoma.Frontiers in oncology · 2024Article
- Depicting the Implication of miR-378a in Cancers.Technology in cancer research & treatmentReview
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe malignant tumor hepatocellular carcinoma (HCC) has a poor prognosis and ineffective therapeutic options. miR-378a-5p is a micro-ribonucleic acid (miRNA) that is overexpressed in many cancers. However, its role in the progression of human HCC is unclear.
methodsQuantitative real-time polymerase chain reaction (qRT-PCR) was used to measure miR-378a-5p levels in tissues from patients with HCC and from HCC cell lines. Following transfection, flow cytometry and cell viability assays were used to measure cell proliferation. HCC cell invasive and migration capacities were assessed using Transwell assays. Western blots were performed with HCC cells to identify the expression of vascular endothelial growth factor (VEGF).
resultsThe HCC tissues and cells had significantly reduced miR-378a-5p expression compared with normal liver tissues and cells, while miR-378a-5p mimics suppressed the colony formation, viability, migration and invasive capacity of HCC cells. The HCC tissues and cell lines had upregulated VEGF expression. In HCC cells, miR-378a-5p expression was negatively correlated with VEGF expression, and miR-378a-5p targeted VEGF in HCC cells.
conclusionsmiR-378a-5p improved the HCC prognosis and suppressed HCC progression by targeting the VEGF pathway.
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Registered trials
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