ArticleTranslational cancer research2020
MicroRNA-643 promotes proliferation and inhibits apoptosis of papillary thyroid carcinoma by down-regulating the cytochrome P450 family member 11B1.
Article in Translational cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Circulating microRNAs and Clinicopathological Findings of Papillary Thyroid Cancer: A Systematic Review.In vivo (Athens, Greece)Pooled it
- RNA-binding protein RBM47 in health and disease: molecular mechanisms, preclinical evidence, and translational challenges.Frontiers in immunology · 2026Review
- The effect of Entamoeba histolytica lectin antigen and microRNA-643 on the development of microsatellite instability (MSI) in colorectal adenocarcinoma.BMC cancer · 2025Article
- Hsa_circ_0018909 promotes non-small cell lung cancer by directly regulating hsa-miR-513b-5p.Frontiers in oncology · 2025Article
- The Application of microRNAs in Papillary Thyroid Cancer: A Bibliometric and Visualized Analysis.International journal of general medicine · 2024Article
- Identification and validation of xenobiotic metabolism-associated prognostic signature based on five genes to evaluate immune microenvironment in colon cancer.Journal of gastrointestinal oncology · 2021Article
- The Importance of miRNA in the Diagnosis and Prognosis of Papillary Thyroid Cancer.Journal of clinical medicine · 2021Review
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThyroid cancer is the most common malignant tumor in endocrine system. Papillary thyroid carcinoma (PTC), accounting for 60-70% of all thyroid cancer cases, is the most common type of thyroid cancer. Nowadays, the treatments for PTC are limited and the prognosis is poor. Exploring the underlying mechanism of PTC development and finding evidence for molecular targeted therapy have always been urgent problems. The purpose of the current study is to investigate the clinical value of microRNA (miR)-643, and its related mechanism regulating PTC proliferation and apoptosis by regulating cytochrome P450 family member 11b1 (CYP11B1).
methodsForty-two confirmed human PTC tissue specimens, corresponding adjacent normal thyroid tissue specimens, and serum samples were collected from September 2018 to April 2019. The transfected cell lines were divided into four groups: control group, empty group, si-miR-643 group, and si-miR-643 + si-CYP11B1 group. Real-time quantitative PCR (qRT-PCR) was used to detect the relative expression of miR-643 and CYP11B1 mRNA. The expression of CYP11B1 protein was detected by Western blot (WB). Cell proliferation was detected by cell counting kit-8 (CCK-8) and colony formation assay. Cell apoptosis was detected by flow cytometry. The dual-luciferase reporter gene assay was used to verify the targeting relationship between miR-643 and CYP11B1.
resultsCompared to adjacent non-tumor tissues, miR-643 expression in PTC tissues was significantly up-regulated (P=0.019). Pearson correlation analysis showed that miR-643 level in serum was significantly correlated with that in PTC tissue (r
conclusionsMiR-643 can promote the proliferation of TPC-1 cells and inhibit its apoptosis through regulating CYP11B1.
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