ArticleTranslational cancer research2020
HSP70 regulates cell proliferation and apoptosis in actinomycin-D-treated lung cancer cells.
Article in Translational cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 4 citations in OpenAlex.
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- Targeting Mitochondrial Dysfunction in Cerebral Ischemia: Advances in Pharmacological Interventions.Antioxidants (Basel, Switzerland) · 2025Review
- Modulating Nitric Oxide: Implications for Cytotoxicity and Cytoprotection.Antioxidants (Basel, Switzerland) · 2024Review
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10 authors at 1 institution in 1 country.
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Abstract
backgroundHeat-shock protein 70 (HSP70) is a member of the heat-shock protein family which is expressed in various types of cancer and associated with apoptosis in cancer cells. However, the role of HSP70 in the regulation of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38MAPK)-dependent growth and apoptosis in lung cancer cells remains largely unknown.
methodsIn this study, we conducted
resultsWe found that treatment of the cells with mild heat and JNK/p38 MAPK pathway inhibitors (SP600125 and SB203580) promoted cell proliferation in the presence of actinomycin D (ActD) in A549 cells. We also showed that treatment with mild heat or SP600125 and SB203580 significantly slowed the steps of apoptosis induced by ActD in A549 cells. Moreover, we found that HSP70 overexpression induced by mild heat markedly decreased the expression of cell growth and apoptosis-related protein p-JNK, p38 and caspase-3. By contrast, knockdown of HSP70 by siRNA HSPAIA-2009 effectively promoted the expression of the JNK and p38 MAPK.
conclusionsOur results indicate that HSP70 plays an important role in lung cancer growth and apoptosis through the activation of JNK and p38 MAPK signaling in actinomycin-D-treated lung cancer A549 cells.
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