ArticleTranslational cancer research2020
Long noncoding RNA UCA1 facilitates cell proliferation and inhibits apoptosis in retinoblastoma by activating the PI3K/Akt pathway.
Article in Translational cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- LncRNAs signatures in gynecological cancers: ovarian and endometrial cancers.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- Post-translational modifications in retinoblastoma: mechanisms, immune regulation, and therapeutic opportunities.Frontiers in immunology · 2026Review
- Molecular Biological Research on the Pathogenic Mechanism of Retinoblastoma.Current issues in molecular biology · 2024Review
- Cell-specific housekeeping role of lncRNAs in COVID-19-infected and recovered patients.NAR genomics and bioinformatics · 2024Article
- Long non-coding RNAs involved in retinoblastoma.Journal of cancer research and clinical oncology · 2023Review
- Retinoblastoma: Review and new insights.Frontiers in oncology · 2022Review
- LncRNA-CASC7 inhibits the proliferation and migration of colon cancer by negatively regulating the PI3K/Akt signaling pathway.Journal of gastrointestinal oncology · 2021Article
- The Role of LncRNAs in Translation.Non-coding RNA · 2021Review
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to explore the effects of the long noncoding RNA (lncRNA)-UCA1 on retinoblastoma (RB) and the potential underlying molecular mechanisms.
methodsThe expression of lncRNA-UCA1 was measured by qRT-RCR in both RB tissues and the RB cell lines HXO-RB44 and Y79. The relationship between lncRNA-UCA1 expression and the clinical characteristics of RB patients was evaluated. Cell proliferation, colony formation, and apoptosis and the cell cycle of HXO-RB44 and Y79 cells were evaluated by the cell counting kit-8 (CCK-8) assay, colony formation assay, and flow cytometry, respectively. In addition, the expression levels of PCNA, caspase-3, survivin, p16, p21, CDK2, PI3K, p-PI3K, Akt, p-Akt, and S6k in HXO-RB44 and Y79 cells were measured by Western blotting.
resultsLncRNA-UCA1 was highly expressed in both RB tissues and the RB cell lines HXO-RB44 and Y79. Moreover, lncRNA-UCA1 expression levels in RB patients were correlated with tumour size, optic nerve invasion, and pathologic grade. LncRNA-UCA1 promoted cell proliferation and cell cycle progression and inhibited apoptosis in HXO-RB44 and Y79 cells. LncRNA-UCA1 overexpression dramatically increased the expression of S6k and the phosphorylation of PI3K and Akt in RB cells. Treatment with the PI3K inhibitor LY294002 reversed the effects of lncRNA-UCA1 on RB cell proliferation, apoptosis, and cell cycle progression.
conclusionsOur study showed that lncRNA-UCA1 could promote cell proliferation and cell cycle progression and inhibit cell apoptosis in RB by activating the PI3K/Akt pathway.
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