ArticleTranslational cancer research2020
microRNA-324 plays an oncogenic role in bladder cancer cell growth and motility.
Article in Translational cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Liquid Biopsy Based Bladder Cancer Diagnostic by Machine Learning.Diagnostics (Basel, Switzerland) · 2025Article
- MicroRNA analysis of medium/large placenta extracellular vesicles in normal and preeclampsia pregnancies.Frontiers in cardiovascular medicine · 2024Article
- Expression and clinical significance of miR-17-5p in tumor tissues of patients with colorectal cancer.Journal of gastrointestinal oncology · 2022Article
- microRNA-324-3p suppresses the aggressive ovarian cancer by targetingBioengineered · 2022Article
- A review on the role of miRNA-324 in various diseases.Frontiers in genetics · 2022Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite advances in the treatment of bladder cancer (BC), patients with late-stage BC have a high mortality rate. microRNA is a small, nonprotein coding RNA, and a dysfunction in its expression is frequently strongly correlated with the prognosis of patients with cancer. Aberrant expression of miR-324 has been reported to contribute to human carcinogenesis. However, the role of miR-324 in BC remains unclear.
methodsThe expression levels of miR-324-5p and miR-324-3p were analyzed by analyzing The Cancer Genome Atlas (TCGA) database and real-time polymerase chain reaction (PCR) approach. The biological role of miR-324-5p and miR-324-3p were assessed in BFTC950 cells with miR-324-5p or miR-324-3p mimics transfection, respectively.
resultsIn this study, we demonstrated that high expression levels of miR-324-5p and miR-324-3p were significantly correlated with poor survival of patients with BC. Furthermore, miR-324-5p expression significantly accelerated BC cell proliferation, colony formation ability, and invasion ability, whereas miR-324-3p expression slightly increased BC cell growth and motility.
conclusionOur data indicated that miR-324-5p and miR-324-3p play oncogenic roles in BC cells. This finding provides a new insight into potential therapeutic targets or putative biomarkers of BC.
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