ArticleTranslational cancer research2020
Construction of dysregulated long non-coding RNA-associated competing endogenous RNA network in uterine corpus endometrial carcinoma.
Article in Translational cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- The Role of miRNAs in the Development, Proliferation, and Progression of Endometrial Cancer.International journal of molecular sciences · 2023Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCompeting endogenous RNAs (ceRNAs) render the functions of long non-coding RNAs (lncRNAs) more complicated during cancer processes. Potential lncRNA biomarkers as ceRNAs have not been clearly described for uterine corpus endometrial carcinoma (UCEC). In this research, we researched the functions and regulatory mechanisms of lncRNAs as ceRNAs in UCEC, and their potential applications in prognosis.
methodsThe lncRNAs, mRNAs, and miRNAs expression profiles including 552 UCEC tissues and 35 non-tumor tissues were downloaded from The Cancer Genome Atlas (TCGA) portal. Differentially expressed mRNAs, miRNAs and lncRNAs were confirmed by R/Bioconductor package of edgeR (|log
resultsA total of 1,102 lncRNAs, 2,612 mRNAs and 189 miRNAs were detected to be dysregulated in UCEC. The newly identified ceRNA network includes 27 UCEC-specific miRNAs, 90 lncRNAs, and 74 mRNAs. Eleven mRNAs, 3 miRNAs (
conclusionsIn our research process, we successfully constructed a lncRNA-associated ceRNA network which will provide a novel perspective for improving the understanding of UCEC. This study also assists in the identification of new potential biomarkers to be used as candidate prognostic biomarkers or potential therapeutic targets.
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