ArticleTranslational cancer research2020
Prognosis and clinicopathological characteristics of renal cell carcinoma: does bilateral occurrence influence overall and cancer-specific survival?
Article in Translational cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Preoperative kidney tumor risk estimation with AI: From logistic regression to transformer.PloS one · 2025Article
- The long-term survival outcome of sporadic bilateral renal cell carcinoma and optimization of surgical treatment: a large-scale population-based cohort study.Clinical and experimental medicine · 2024Observational
- Same Organ, Two Cancers: Complete Analysis of Renal Cell Carcinomas and Upper Tract Urothelial Carcinomas.Medicina (Kaunas, Lithuania) · 2024Article
- Stemness-associated senescence genes as potential novel risk factors for papillary renal cell carcinoma.Translational andrology and urology · 2021Article
- Tumor volume: a new prognostic factor of oncological outcome of localized clear cell renal cell carcinoma.BMC cancer · 2021Article
- Nomograms to predict overall and cancer-specific survival in patients with penile cancer.Translational cancer research · 2020Article
- Nonfamilial Bilateral Synchronous Renal Cell Carcinoma with Discordant Histology with Eventual Complete Response to Dual Immunotherapy.Case reports in oncologyArticle
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Authors and funding
6 authors.
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Abstract
backgroundTo compare clinicopathological characteristics and prognosis of bilateral and unilateral renal cell carcinoma.
methodsData from patients who had been diagnosed with renal cell carcinoma (RCC) and undergone radical nephrectomy (RN) from 2004 to 2014 were extracted from the Surveillance, Epidemiology, and End Results (SEER) registry. The χ
resultsThe study cohort comprised 41,573 patients. A nonlinear relationship between age and OS and CSS was identified with and without adjusting for potential factors. Threshold effect analysis revealed that ages 54 and age 74 were the turning points associated with changes in OS and CSS, respectively. Multivariate Cox regression analysis demonstrated that age category, race, grade, and T, N, and M stage were prognostic factors for OS and CSS of patients with RCC. Additionally, sex and pathology were significantly associated with OS.
conclusionsBilateral occurrence does not influence OS and CSS in patients with RCC who have undergone RN. The risk of poor OS and CSS was higher with greater age category, tumor grade, and T stage. Patients in different age categories (<54, ≥54 and <74, ≥74 years) may benefit from individualized attention and therapeutic strategies.
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