Evidence map›Paper›PMID 35117356›Full record

ArticleTranslational cancer research2020

Druggable driver gene alterations in redefined large cell carcinoma in Chinese patients: an observational study.

Jinhua Yang, Yuping Li, Benting Ma, Huikang Xie, Linsong Chen, Xuejuan Gao, Wenxin He

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. The impact of sex on setup accuracy in radiotherapy for rectal cancer: a real-World observational study.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026
    Observational
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Jinhua Yang *Department of Respiratory and Critical Care Medicine, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, China.
Yuping Li *Department of Thoracic Surgery, Shanghai Pulmonary Hospital Affiliated to Tongji University, Shanghai, China.
Benting Ma *Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China.
Huikang XieDepartment of Pathology, Shanghai Pulmonary Hospital Affiliated to Tongji University, Shanghai, China.
Linsong ChenDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital Affiliated to Tongji University, Shanghai, China.
Xuejuan GaoBaylorOracle, Hangzhou, China.
Wenxin HeDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital Affiliated to Tongji University, Shanghai, China.
Shanghai Pulmonary Hospital · CNTongji University · CNChangzhi Medical College · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFew reports have investigated the genetic status of large cell carcinoma (LCC) in Chinese patients under the 2015 World Health Organization (WHO) classification. We aimed to analyze the distribution of druggable driver gene alterations, including mutations in epidermal growth factor receptor (

methodsA cohort of 322 patients with LCC resected between June 2015 and December 2018 was included in this study. The clinical characteristics of the patients and data on the distribution of

resultsAmong the patients with redefined LCC, the proportion of males was much higher than that of females. Detection of LCC was more frequent in patients >60 years of age (71.4%). Mutations of

conclusionsUnder the 2015 WHO criteria, LCC was more frequently detected in elderly male patients with inferior prognoses. The frequency of

Indexed as

EGFR mutationGene alterationsKRAS mutationlarge cell carcinoma (LCC)

Identifiers

PMID35117356
PMCPMC8799145
OpenAlexW3117254816

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.