Evidence map›Paper›PMID 35117238›Full record

ArticleTranslational cancer research2020

Prognostic value of immune-related genes in laryngeal squamous cell carcinoma.

Weixing Liu, Chunyi Zhang, Xin Gong, Wenjing Liao, Jun Xu, Xiaowen Zhang

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Article in Translational cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
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5citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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5 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Weixing Liu *State Key Laboratory of Respiratory Disease, Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Chunyi Zhang *State Key Laboratory of Respiratory Disease, Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Xin GongState Key Laboratory of Respiratory Disease, Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Wenjing LiaoState Key Laboratory of Respiratory Disease, Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Jun XuState Key Laboratory of Respiratory Disease, Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Xiaowen ZhangState Key Laboratory of Respiratory Disease, Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLaryngeal squamous cell carcinoma (LSCC) is a very common cancer in head and neck. A large amount of evidence indicated that immune genes take a non-negligible part in the occurrence and development of LSCC. We aimed to evaluate the prognostic value of the immune-related genes (IRGs) in LSCC.

methodsWe analyzed the expression profiles of IRGs and clinical information of patients from The Cancer Genome Atlas (TCGA) dataset, including one hundred and fourteen LSCC and eleven non-tumor tissues. The uncover molecular mechanisms of these survival-associated IRGs (SAIRGs) were explored by the bioinformatics analyses. A novel prognostic model based on IRGs was developed through multivariate Cox regression.

resultsTwenty-seven differentially expressed SAIRGs in LSCC patients. Copy number alterations, protein-protein interaction (PPI) network, transcription factors (TFs) regulate network were used to identify molecular characteristics of these IRGs. We established an IRGs (

conclusionsIRGs have a potential role in the occurrence and development of LSCC, and the IRGPM can predict the overall survival rate of LSCC.

Indexed as

bioinformatics analysesimmune genesLaryngeal squamous cell carcinoma (LSCC)markersprognostic model

Identifiers

PMID35117238
PMCPMC8798985

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