ArticleTranslational cancer research2020
Clinicopathological characteristics and survival outcomes of younger patients with gastric cancer: a systematic review and meta-analysis.
Article in Translational cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Real-world insights into young-onset gastroesophageal adenocarcinoma: an all-Ireland population-based cancer registry analysis.ESMO gastrointestinal oncology · 2026Article
- Population-Based Study of Gastric Cancer Survival and Associations in Rural Western Honduras.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Efficacy and safety of chemotherapy in young patients with advanced gastroesophageal adenocarcinoma: data from the Spanish AGAMENON-SEOM registry.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2024Article
- Aggressive Histology and Extensive Metastasis Characteristic of Very Young Gastric Cancer (Less Than 30 Years): A Retrospective Clinical Audit.South Asian journal of cancer · 2023Article
- Article
- Early-Onset Gastric Cancer from a Geographic Area of High Gastric Cancer Incidence in North-East India: a Retrospective Study.Indian journal of surgical oncology · 2023Article
- Clinical Characteristics and Oncological Outcomes of Surgically Treated Early-Onset Gastric Adenocarcinoma - a Retrospective Cohort Study.Journal of Cancer · 2023Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSurvival outcomes of gastric cancer in younger patients have been reported in several studies with controversial results. This systematic review and meta-analysis investigated the clinicopathological characteristics, postoperative complications, and survival outcomes between younger and older patients.
methodsWe systematically reviewed clinical researches from PubMed, The Cochrane Library, Embase, and Web of science published up to December 2019. The effect size for the included studies was estimated with the odds ratio (OR). Heterogeneity was investigated using the χ
resultsA total of 25 clinical studies involving 81,188 gastric cancer patients were included in this meta-analysis, of which one was a prospective study. Younger patients were more likely to be females, pTNM stage IV and peritoneal metastasis. The incidence of postoperative complications, lymph node metastasis, as well as hepatic metastasis of younger patients was significantly lower than that of the older. There was no statistical difference in overall survival (OS) between the younger and older patients with gastric cancer. After stratification for patients with gastrectomy, however, younger patients were associated with a better 5-year OS relative to older patients.
conclusionsIn conclusion, younger patients with gastric cancer were more often diagnosed as poorly differentiation and later pTNM tumor stage. However, younger cancer patients following gastrectomy had a better OS rate than patients in older group. Future large-scale analyses are expected to confirm our findings.
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