Evidence map›Paper›PMID 35117184›Full record

ArticleTranslational cancer research2020

Differences in lower cranial nerve complications predicted by the NTCP model between RTOG and reduced-volume IMRT planning in radiotherapy for nasopharyngeal carcinoma.

Jianjun Qian, Yongqiang Yang, Pengfei Xing, Cuihong Wang, Ye Tian, Xueguan Lu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jianjun Qian *Department of Radiotherapy & Oncology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
Yongqiang Yang *Department of Radiotherapy & Oncology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
Pengfei XingDepartment of Radiotherapy & Oncology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
Cuihong WangDepartment of Radiology, Fudan University Shanghai Cancer Hospital, Shanghai 200032, China.
Ye TianDepartment of Radiotherapy & Oncology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
Xueguan LuDepartment of Radiation Oncology, Fudan University Cancer Hospital, Shanghai 200032, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to assess the differences in lower cranial nerve (LCN) complications predicted by the normal tissue complication probability (NTCP) model between Radiation Therapy Oncology Group (RTOG) and reduced-volume intensity-modulated radiotherapy (IMRT) planning for nasopharyngeal carcinoma (NPC) radiotherapy.

methodsA total of fifty patients with NPC were divided into two groups according to T-stages of T1-2 and T3-4, and the LCNs of each patient were contoured on CT simulation images. The targets were contoured based on the RTOG 0225 clinical trial and a working committee for clinical stage NPC in China in 2010. The NTCP differences in LCNs between the two plans were calculated.

resultsThe LCN volume of the 50 patients was 10.07 cc. The Dmax and Dmean of LCNs in RTOG plans were significantly larger than those in reduced-volume plans (7,453

conclusionsthe clinical T-stage, a high Dmean and a large irradiation volume are important factors in predicting LCN complications. Of the two most common IMRT guidance plans in China, the LCN NTCP based on the reduced-volume plan is significantly lower than that based on the RTOG plan.

Indexed as

intensity-modulated radiotherapy (IMRT)lower cranial nerves (LCNs)Nasopharyngeal carcinoma (NPC)normal tissue complication probability (NTCP)

Identifiers

PMID35117184
PMCPMC8798443

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.