Evidence map›Paper›PMID 35117167›Full record

ArticleTranslational cancer research2020

The correlation between DNA mismatch repair status and the clinicopathological and molecular features of Chinese sporadic colorectal cancer.

Cong Li, Fangqi Liu, Dan Huang, Yuchen Wu, Zhimin Wang, Ye Xu

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Cong LiDepartment of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Fangqi LiuDepartment of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Dan HuangDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Yuchen WuDepartment of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Zhimin WangDepartment of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center and Shanghai Academy of Science & Technology, Shanghai 201203, China.
Ye XuDepartment of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Fudan University Shanghai Cancer Center · CNShanghai Academy of Science & Technology · CNShanghai Medical College of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDNA mismatch repair (

methodsWe evaluated 1,405 patients who had undergone primary tumour resection, and divided them into MMR deficiency (dMMR) and MMR proficiency (pMMR) groups, according to their

resultsThe dMMR group contained 125 patients and the pMMR group contained 1 280 patients. Patients with dMMR were more likely to be younger (P<0.05), have poorly differentiated tumours (14.6%), tumours with negative peripheral nerve invasiveness (10.2%), and right-side tumours. Multivariate analysis revealed that the significant independent risk factors for dMMR-related CRC were younger age (OR: 0.979, 95% CI: 0.960-0.998), larger tumour diameter (OR: 1.313, 95% CI: 1.162-1.484), poor differentiation, no peripheral nerve invasiveness (OR: 3.018, 95% CI: 1.258-7.239), right-side colon cancer (OR: 10.821, 95% CI: 4.895-23.922), Bcl-2 positivity (OR: 0.209, 95% CI: 0.095-0.458), topoisomerase II negativity (OR: 3.333, 95% CI: 1.563-7.103) and glutathione S-transferase (GST) negativity (OR: 1.748, 95% CI: 1.009-3.027).

conclusionsYounger age, poorly differentiated tumours, negative peripheral nerve invasiveness, right-side tumours, Bcl-2 positivity, topoisomerase II negativity and GST negativity increased the likelihood of dMMR in Chinese patients with sporadic CRC.

Indexed as

colorectal cancer (CRC)microsatellite instability (MSI)Mismatch repair (MMR)

Identifiers

PMID35117167
PMCPMC8797765
OpenAlexW3000275343

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.