ArticleTranslational cancer research2019
LncRNA-DANCR promotes growth and metastasis of colorectal cancer via activating epithelial-mesenchymal transition process.
Article in Translational cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- The lncrnas: innovative multifunctional players of drug resistance in colorectal cancer.Cancer cell international · 2025Review
- LncRNA-DANCR Promotes ESCC Progression and Function as ceRNA to Regulate DDIT3 Expression by Sponging microRNA-3193.Cancer science · 2025Article
- Exploring the interplay of natural products and long non-coding RNAs in colorectal cancer: pathogenesis, diagnosis, and overcoming drug resistance.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Activation of lncRNA DANCR by H3K27 acetylation regulates proliferation of colorectal cancer cells.Discover oncology · 2024Article
- New evidence for a role of DANCR in cancers: a comprehensive review.Journal of translational medicine · 2024Review
- A review on the role of DANCR in the carcinogenesis.Cancer cell international · 2022Review
- Development of a novel hypoxia-immune-related LncRNA risk signature for predicting the prognosis and immunotherapy response of colorectal cancer.Frontiers in immunology · 2022Article
- Long non-coding RNA LINC00997 silencing inhibits the progression and metastasis of colorectal cancer by sponging miR-512-3p.Bioengineered · 2021Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to investigate the effects and underlying mechanism of long non-coding RNA-differentiation antagonizing non-protein coding RNA (lncRNA-DANCR) on colorectal cancer (CRC).
methodsThe expression of lncRNA-DANCR in CRC and pericarcinous tissues from 40 CRC patients, and the expression in HT-29 cells and FHC cells, were determined by qRT-PCR. Cell proliferation was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. The migration and invasion of CRC cells were detected by wound healing assay and transwell assay, respectively. HT-29 cells were transfected and divided into three groups: BLANK group, si-NC group and si-DANCR group. After transfection, the expression of lncRNA-DANCR was detected by qRT-PCR. The expression of E-cadherin and vimentin was detected by western blot and immunofluorescence. The mice model of xenograft tumor was established and histological changes of lung lobes sections were measured by hematoxylin-eosin (HE) staining.
resultsThe expression of lncRNA-DANCR in CRC tissues and HT-29 cells was significantly higher than that in non-CRC tissues and FHC cells. Silencing lncRNA-DANCR could significantly inhibit the proliferation, invasion and metastasis of HT-29 cells. Western blot showed that the expression of E-cadherin increased significantly and vimentin decreased significantly after silencing lncRNA-DANCR. The same results were observed in immunofluorescence experiment. Silence of lncRNA-DANCR markedly suppressed the growth and metastasis of CRC.
conclusionsLncRNA-DANCR may facilitate the growth and metastasis of CRC by regulating the epithelial-mesenchymal transition (EMT) process.
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