ArticleTranslational cancer research2019
Serum oxidative stress is an independent prognostic marker in colorectal cancer.
Article in Translational cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Oxidative Status and Lipid Metabolism Analytes in Dogs with Mast Cell Tumors: A Preliminary Study.Antioxidants (Basel, Switzerland) · 2024Article
- Article
- Monitoring Metastatic Colorectal Cancer Progression According to Reactive Oxygen Metabolite Derivative Levels.Cancers · 2023Article
- Targeting Mitochondria and Oxidative Stress in Cancer- and Chemotherapy-Induced Muscle Wasting.Antioxidants & redox signaling · 2023Review
- Oxidative Stress and DNA Damage Markers in Colorectal Cancer.International journal of molecular sciences · 2022Article
- Sam68 promotes aerobic glycolysis in colorectal cancer by regulating PKM2 alternative splicing.Annals of translational medicine · 2020Article
- Prognostic Value of Oxidative Stress Markers in Patients with Pulmonary Arterial or Chronic Thromboembolic Pulmonary Hypertension.Oxidative medicine and cellular longevity · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFew previous studies have investigated the relationship between serum oxidative stress and the status of patients with colorectal cancer. Our aim in the current study was to investigate the significance of serum oxidative stress as a prognostic marker in these patients.
methodsThe subjects were 53 patients who underwent curative resection of high-risk stage II or stage III colorectal cancer. The correlation of serum oxidative stress (Reactive Oxygen Metabolites Test: d-ROMs Test) with recurrence-free survival was examined.
resultsThere were no significant differences in d-ROMs between the recurrence and non-recurrence groups at four time points (0M: before the start of postoperative adjuvant chemotherapy; and 1M: 1 month; 3M: 3 months; and 6M: 6 months after the start of postoperative adjuvant chemotherapy). Only the 3M/0M d-ROMs (the value at 3M relative to the value at 0M) was increased compared with the other time points in the recurrence group, as well as with all time points in the non-recurrence group. In univariate analysis, there were significant differences in recurrence-free survival with respect to N classification (P=0.004) and 3M/0M d-ROMs (P=0.002). In multivariate analysis, both N classification and serum oxidative stress were found to be significant independent prognostic factors (P=0.02, HR=4.49; P=0.02, HR=5.61, respectively).
conclusionsThe results of this study demonstrate the prognostic value of serum oxidative stress in colorectal cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.