Evidence map›Paper›PMID 35116881›Full record

ArticleTranslational cancer research2019

Stereotactic body radiation therapy or surgery for stage I-II non-small cell lung cancer treatment?-outcomes of a meta-analysis.

Qiuning Zhang, Lihua Shao, Jinhui Tian, Ruifeng Liu, Yichao Geng, Yiran Liao, Hongtao Luo, Long Ge, Shuangwu Feng, Xiaohu Wang and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Role of Nanoformulations in the Treatment of Lung Cancer.Recent patents on nanotechnology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Qiuning Zhang *Department of Radiation Oncology, The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China.
Lihua Shao *Department of Radiation Oncology, The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China.
Jinhui TianKey Laboratory of Clinical Translational Research and Evidence-based Medicine of Gansu Province, Lanzhou University, Lanzhou 730000, China.
Ruifeng LiuDepartment of Radiation Oncology, The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China.
Yichao GengDepartment of Radiation Oncology, The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China.
Yiran LiaoDepartment of Radiation Oncology, The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China.
Hongtao LuoDepartment of Radiation Oncology, The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China.
Long GeKey Laboratory of Clinical Translational Research and Evidence-based Medicine of Gansu Province, Lanzhou University, Lanzhou 730000, China.
Shuangwu FengDepartment of Radiation Oncology, The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China.
Xiaohu WangDepartment of Radiation Oncology, The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China.
Zhen YangBasic Medical College of Lanzhou University, Lanzhou 730000, China.
Lanzhou University · CNGansu Provincial Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStereotactic body radiotherapy (SBRT) has been increasingly recognized as a favourable alternative to surgical resection for early-stage non-small cell lung cancer (NSCLC). Many retrospective analyses compared the efficacy of SBRT with that of surgery for NSCLC. However, the difference in efficacy between SBRT and surgery in patients with early-stage NSCLC remains unclear.

methodsWe searched PubMed, the Cochrane Library, EMBASE and the Chinese Biomedical Literature Database from inception to March 14, 2018, to identify studies comparing SBRT with surgery in the treatment of stage I/II NSCLC. STATA 12.0 software was used to perform the meta-analysis.

resultsA total of 15 studies that carried out propensity score matching (PSM) were included. In this meta-analysis, patients with SBRT had worse overall survival (OS) than those with surgery, but the analysis restricting studies to the same adjustment factors showed that the difference in OS gradually decreased with the increase in comparable matching characteristics between the two groups and that there was eventually no significant difference. Patients treated with SBRT achieved similar cause-specific survival (CSS), local control, regional control, loco-regional control, and distant control compared with surgery. In addition, a separate analysis of 6 studies that compared SBRT with lobectomy also showed that with the increase in comparable matching characteristics between surgery and SBRT, the OS differences gradually decreased, and there was eventually no significant difference.

conclusionsIn this study, we found more favourable OS for stage I/II NSCLC treated with surgery, but when there were increasing numbers of comparable matching characteristics between surgery and SBRT, the differences in the survival rate were reduced to the point that they were not significant. The CSS and recurrence (local, regional, or disseminated) differences between surgery and SBRT were also not significant. Therefore, SBRT has the potential to be an alternative to surgical treatment in patients with stage I/II NSCLC, but these findings need to be confirmed by large-sample, long-term follow-up randomized clinical studies.

Indexed as

Meta-analysisstage I/II non-small cell lung cancer (NSCLC)stereotactic ablative radiotherapy (SABR)stereotactic body radiotherapy (SBRT)surgery

Identifiers

PMID35116881
PMCPMC8798261
OpenAlexW4210332219

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.