ArticleTranslational cancer research2019
The expression profile of RNA sensors in colorectal cancer and its correlation with cancer stages.
Article in Translational cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- DDX21 at the Nexus of RNA Metabolism, Cancer Oncogenesis, and Host-Virus Crosstalk: Decoding Its Biomarker Potential and Therapeutic Implications.International journal of molecular sciences · 2024Review
- Algorithmic Programming of Sequential Logic and Genetic Circuits for Recording Biochemical Concentration in a Probiotic Bacterium.ACS synthetic biology · 2023Article
- Role and therapeutic potential of DEAD-box RNA helicase family in colorectal cancer.Frontiers in oncology · 2023Review
- Risk stratification of patients with right-sided colorectal cancer based on the tumor-infiltrating M1 macrophage.American journal of cancer research · 2022Article
- Endoscopic submucosal dissection in the treatment of patients with early colorectal carcinoma and precancerous lesions.Journal of gastrointestinal oncology · 2020Article
- Upregulation of STAT1-CCL5 axis is a biomarker of colon cancer and promotes the proliferation of colon cancer cells.Annals of translational medicine · 2020Article
- Dysregulation in nucleic acid-sensing pathway genes is associated with cancer patients' prognosis.Cancer science · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRNA sensors represent the most important pattern recognition receptors (PRRs) to defend against RNA pathogens, such as RNA viruses. Recent studies revealed their critical roles in inflammatory and autoimmune diseases. Furthermore, more recent evidences indicated that RNA sensors mediate the development of colitis or colorectal cancer (CRC). However, a systematic understanding of RNA sensors in CRC is still lacking, especially the expression patterns in CRC.
methodsHere, we analyzed RNA sensor expression, clinical significance, and possible mechanisms in CRC by combining bioinformatic analysis and the analysis on pre-cancerous animal model and clinical tissue samples.
resultsWe found that most of the members of RNA sensors, including RNA-sensing Toll-like receptors (
conclusionsThis study reveals the potential values of RNA-sensing genes including TLRs,
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Registered trials
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