Evidence map›Paper›PMID 35116827›Full record

ArticleTranslational cancer research2019

The molecular basis for p53 inhibition of autophagy in porcine fibroblast cells.

Jimin Fei, Anyong Xu, Wen Zeng, Yukun Liu, Deling Jiao, Wanyun Zhu, Kaixiang Xu, Honghui Li, Hong-Jiang Wei, Hong-Ye Zhao

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Role of BCAR4 in prostate cancer cell autophagy.Translational andrology and urology · 2021
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Jimin Fei *The Third Affiliated Hospital of Kunming Medical University, The Tumor Hospital of Yunnan Province, Kunming 650201, China.
Anyong Xu *Key Laboratory of Animal Gene Editing and Animal Cloning in Yunnan Province, Kunming 650201, China.
Wen ZengThe Third Affiliated Hospital of Kunming Medical University, The Tumor Hospital of Yunnan Province, Kunming 650201, China.
Yukun LiuKey Laboratory of Animal Gene Editing and Animal Cloning in Yunnan Province, Kunming 650201, China.
Deling JiaoKey Laboratory of Animal Gene Editing and Animal Cloning in Yunnan Province, Kunming 650201, China.
Wanyun ZhuCollege of Pharmacy and Chemistry, Dali University, Dali 671000, China.
Kaixiang XuKey Laboratory of Animal Gene Editing and Animal Cloning in Yunnan Province, Kunming 650201, China.
Honghui LiKey Laboratory of Animal Gene Editing and Animal Cloning in Yunnan Province, Kunming 650201, China.
Hong-Jiang WeiKey Laboratory of Animal Gene Editing and Animal Cloning in Yunnan Province, Kunming 650201, China.
Hong-Ye ZhaoKey Laboratory of Animal Gene Editing and Animal Cloning in Yunnan Province, Kunming 650201, China.
Yunnan Animal Science and Veterinary Institute · CNDali University · CNKunming Medical University · CNYunnan Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAutophagy regulation involves an intricate network that can degrade and recycle cytosolic components in autophagosomes when cells are subject to various stress signals. p53 plays a dual role of induction or inhibition in the regulation of autophagy. Recently, pigs have been considered an excellent large animal model for their many anatomical and physiological similarities to humans. Here, we investigated the relationship between p53 and autophagy, as well as the underling molecular basis, in porcine fibroblast cells (PFCs).

methodsAutophagy was induced by Earle's balanced salt solution (EBSS) in p53

resultsWe found that the increased expression of LC3-II and the decreased expression of P62 occurred earlier in p53

conclusionsp53

Indexed as

autophagyautophagy-related genes (ATG)autophagy signaling pathway-related genesp53porcine fibroblast cells

Identifiers

PMID35116827
PMCPMC8798480
OpenAlexW4230983221

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.