ArticleTranslational cancer research2019
Risk factors for benign anastomotic stricture post-oesophagectomy: single-centre analysis of 702 oesophagectomies with squamous cell carcinoma.
Article in Translational cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.
- Risk factors for esophageal anastomotic stricture after esophagectomy: a meta-analysis.BMC cancer · 2024Pooled it
- Predicting Anastomotic Leak After Neoadjuvant Chemoimmunotherapy and Esophagectomy: A Dynamic Inflammatory and Nutritional Biomarker Model.Journal of inflammation research · 2026Article
- Short-term Outcomes of Linear vs. Circular Stapling for Esophagojejunostomy in Gastric Cancer: an Inverse Probability of Treatment Weighting Analysis.Journal of gastric cancer · 2025Article
- The Effect of Laparoscopic Gastric Ischemic Preconditioning Prior to Esophagectomy on Anastomotic Stricture Rate and Comparison with Esophagectomy-Alone Controls.Annals of surgical oncology · 2024Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBenign stricture formation after oesophagectomy makes a considerable impact on postoperative recovery, nutritional status and quality of life. Our aim was to investigate the incidence and risk factors for benign anastomotic stenosis post-oesophagectomy in a large series of patients.
methodsWe conducted a retrospective study of all patients undergoing oesophagectomy of oesophageal squamous cell carcinoma (ESCC) in our department from August 2012 to May 2013. Anastomotic stricture was identified clinically and radiologically. A total of 14 clinicopathological variables were assessed by univariate and multivariate logistic regression analyses.
resultsThe study included 702 patients, and anastomotic stricture occurred in 62 patients (8.8%), which was significantly higher after cervical (20.8%) anastomosis than below (7.4%) or above (6.6%) aortic arch anastomosis. The anastomotic stricture rate was 31.8% in single-layer hand sewn (s-HS) anastomosis, 11.7% in circular stapled (CS) anastomosis, 10.4% in double-layer hand-sewn (d-HS) anastomosis and 1.9% in semi-mechanical (SM) anastomosis. The univariate analysis found that hypertension, surgical approach, anastomotic technique, anastomosis site, total number of removed lymph node and anastomotic leakage were associated with anastomotic stricture rate (P<0.05). Age, gender, body mass index (BMI), history of smoking or diabetes, the length of tumour, pT stage, pN stage and historical grading showed no statistically significant difference in the incidence of benign stenosis (P>0.05). On multivariate analysis, anastomosis site (P=0.006) and anastomotic technique (P<0.001) were independently associated with stricture risk.
conclusionsOur study highlighted that patients with ESCC undergoing cervical anastomosis should be cautiously monitored postoperatively as a result of relative high stricture rate. SM technique is the preferred method of oesophago-gastric anastomosis due to a decreased stricture formation compared with other techniques.
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