ArticleTranslational cancer research2019
MiR-451 suppresses the growth, migration, and invasion of prostate cancer cells by targeting macrophage migration inhibitory factor.
Article in Translational cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Combinatorial Analysis of miRNAs and tRNA Fragments as Potential Biomarkers for Cancer Patients in Liquid Biopsies.Non-coding RNA · 2025Article
- Macrophage Migration Inhibitory Factor (MIF) and D-Dopachrome Tautomerase (DDT): Pathways to Tumorigenesis and Therapeutic Opportunities.International journal of molecular sciences · 2024Review
- Regulation of immune cells by miR-451 and its potential as a biomarker in immune-related disorders: a mini review.Frontiers in immunology · 2024Review
- Haplotypes of [-794(CATT)Molecular genetics & genomic medicine · 2023Article
- Reciprocal Dysregulation of MiR-146b and MiR-451 Contributes in Malignant Phenotype of Follicular Thyroid Tumor.International journal of molecular sciences · 2020Article
- Plasma Level Of miR-21 And miR-451 In Primary And Recurrent Breast Cancer Patients.Breast cancer (Dove Medical Press) · 2019Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMetastasis is the most common cause of death of prostate cancer patients. Identification of key regulators in prostate cancer metastasis is essential for improved management of the disease. Accumulation of evidence suggests that miRNAs play important roles in cancer metastasis. Here, we investigated the role of miR-451 in prostate cancer progression and metastasis.
methodsIn this study, we performed reverse transcription-quantitative PCR analysis to examine the expression of miR-451 in clinical prostate cancer samples and cell lines. TargetScan Release 7.0 programs, luciferase reporter assay, and a rescue experiment were used to validate the direct target of miR-451. The protein expression of the miR-451 target was detected by Western blot. MTS cell viability assay, transwell migration assay, and modified Boyden chamber invasion assay were used to demonstrate the effects of increased miR-451 expression on prostate cancer cell growth, migration and invasiveness.
resultsWe identified the decreased expression of miR-451 in clinical metastatic prostate cancer compared to localized primary prostate cancer and benign prostate. Consistently, we also observed the decreased expression of miR-451 in highly metastatic prostate cancer cell lines (C4-2 and PC3M) compared to their low metastatic counterparts (LNCaP and PC3). Furthermore, we confirmed the macrophage migration inhibitory factor (MIF) is a direct target of miR-451 in prostate cancer and demonstrated a negative correlation between miR-451 and MIF expression in clinical prostate cancer samples. Functional studies showed increased miR-451 expression significantly suppressed cell growth, migration and invasiveness via targeting MIF. The effect of increased miR-451 expression can be reversed by overexpressing MIF in prostate cancer cells.
conclusionsThese findings suggest that miR-451 suppresses prostate cancer cell growth, migration and metastasis, which provides insight into the development of novel therapeutic approaches for prostate cancer treatment.
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