ArticleTranslational cancer research2019
The high expression of TNF-α and NF-κB in tumor microenvironment predicts good prognosis of patients with BCLC-0-B hepatocellular carcinoma.
Article in Translational cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Bioinformatics mining and clinical validation of CD274 as a prognostic indicator in hepatocellular carcinoma.BMC cancer · 2026Article
- Tumor Necrosis Factor-Alpha and Adiponectin in Nonalcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma.Cancers · 2023Review
- Detection of sFas, sCD137, and IL-27 Cytokines as Potential Biomarkers for Hepatocellular Carcinoma Diagnosis.Journal of hepatocellular carcinoma · 2023Article
- Specific S100 Proteins Bind Tumor Necrosis Factor and Inhibit Its Activity.International journal of molecular sciences · 2022Article
- Inflammation induced by lipopolysaccharide advanced androgen receptor expression and epithelial-mesenchymal transition progress in prostatitis and prostate cancer.Translational andrology and urology · 2021Article
- Hyperion imaging system reveals heterogeneous tumor microenvironment of oral squamous cell carcinoma patients at T1N0M0 stage.Annals of translational medicine · 2020Article
- Exosomal miR-29b from cancer-associated fibroblasts inhibits the migration and invasion of hepatocellular carcinoma cells.Translational cancer research · 2020Article
- Dynamic Changes of Cytokine Profiles and Their Correlation With Tumor Recurrence Following Thermal Ablation in Hepatocellular Carcinoma.Technology in cancer research & treatmentArticle
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn hepatocellular carcinoma (HCC), inflammatory factors play an important role, but their effects on the prognosis of patients with HCC are still not very clear.
methodsImmunohistochemical staining was used to detect the expression of tumor necrosis factor-alpha (TNF-α) and nuclear factor-kappa B (NF-κB) in tumour tissues of Barcelona Clinic Liver Cancer-0-B stage (BCLC-0-B) patients with HCC. The relationship between TNF-α and NF-κB expression and clinicopathological features was analysed by χ
resultsPatients with HCC had significantly longer survival times in the TNF-α/NF-κB high-coexpression group (P<0.05). High expression of TNF-α and NF-κB is an independent prognostic factor predicting postoperative survival and recurrence in patients with HCC (P<0.05).
conclusionsHigh expression of TNF-α and NF-κB in the HCC microenvironment can predict survival, and patients with high expression have longer survival times and slowing the recurrence time than those in the low-expression group.
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