ArticleTranslational cancer research2019
Circular RNA hsa_circ_0002124 promotes hepatocellular carcinoma cell proliferation through the MAPK pathway.
Article in Translational cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 7 citations in OpenAlex.
- Crosstalk between circRNAs and the MAPK signaling pathway in cancer progression.Discover oncology · 2026Review
- METTL3-mediated m6A modification of circCDKAL1 regulates macrophage M1 polarization and nasal epithelial cell barrier function in allergic rhinitis through IGF2BP2/JARID2/HMGB1 axis.Cell death discovery · 2025Article
- Research progress on NUSAP1 and its role in digestive system neoplasms.Frontiers in oncology · 2025Review
- Non-Coding RNA Related to MAPK Signaling Pathway in Liver Cancer.International journal of molecular sciences · 2022Review
- Testis-specific protein Y-encoded 1 regulates androgen receptor expression through the MAPK/ERK pathway in male hepatocellular carcinoma.Saudi medical journal · 2022Article
- Construction and analysis of the ceRNA networkAnnals of translational medicine · 2021Article
- Circular RNAs regulate cancer-related signaling pathways and serve as potential diagnostic biomarkers for human cancers.Cancer cell international · 2021Review
- Circular RNA is a popular molecule in tumors of the digestive system (Review).International journal of oncology · 2020Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHsa_circ_0002124, which was first reported in 2013, is derived from
methodsFirst, hsa_circ_0002124 was structurally validated via specific convergent and divergent primer amplification. The hsa_circ_0002124 expression in the liver cancer tissues and multiple HCC cell lines were determined using qPCR. Further, the cell functions of hsa_circ_0002124 in HCC cells were examined using knockdown and overexpressed hsa_circ_0002124 in 97H cells. The cell proliferation was assessed using MTS assay, cell proliferation and invasion capacities were evaluated using Transwell culture system, and cell cycle progression and apoptosis were analyzed using flow cytometry. Further, GO and KEGG analyses were performed to uncover the key function and pathways in HCC. The interaction networks between hsa_circ_0002124 and its downstream miRNAs and genes were constructed using Cytoscape software. The key protein expressions (p-JNK, JNK, p-ERK, ERK, p-P38, P38, and c-Myc) of the MAPK pathway in 97H cells with knockdown and overexpressed hsa_circ_0002124 treatments were detected using Western blotting.
resultsHsa_circ_0002124 was highly expressed in the HCC cells and liver cancer tissues. Moreover, the knockdown hsa_circ_0002124 in 97H cells resulted in the repression of cell proliferation, cell invasion, and migration, with simultaneous promotion of cell apoptosis and cell cycle transformation. The opposing situations of cell function could be detected in overexpressed hsa_circ_0002124 in 97H cells. KEGG and interaction network analysis of hsa_circ_0002124 indicated that hsa_circ_0002124 could be a molecular sponge of miRNAs, which regulates the key protein expressions in the MAPK pathway. The p-JNK/JNK, p-ERK/ERK, p-P38/P38, and c-Myc expressions in knockdown hsa_circ_0002124-treated 97H cells were significantly lower than in normal 97H cells, whereas these expressions in overexpressed hsa_circ_0002124-treated 97H cells were significantly higher than in mock vector-treated 97H cells.
conclusionsHsa_circ_0002124 could be a potential biomarker for the early diagnosis and treatment of HCC.
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