ArticleTranslational cancer research2019
Cytotoxic effect of Ad-ephrinA1-caspase-3-T on breast cancer cells
Article in Translational cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors at 1 institution in 1 country.
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Abstract
backgroundResearch whether the Ad-ephrinA1-caspase-3-T has a targeted cytotoxic effect on breast cancer cells
methodsFirst, the breast cancer cells were isolated, cultured and identified. The Ad-ephrinA1-caspase-3-T was used to infect human breast cells, and detect the effect that Ad-ephrinA1-caspase-3-T made on the viability of breast cancer cells with EphA2 positive by MTT. The effect of Ad-ephrinA1-caspase-3-T on the apoptosis of breast cancer cells was detected by flow cytometer. Finally, the specific cytotoxic effect of Ad-ephrinA1-caspase-3-T on target cells was examined by antibody neutralization experiments.
resultsBreast cancer cells showed adherent growth, and high levels of EphA2 receptor and ephrinA1 expression were seen in breast cancer cells. Ad-ephrinA1-caspase-3-T showed a strong cytotoxic effect on breast cancer cells, and the growth inhibition rate was 42.3%. After culture for 72 h, the apoptosis rates corresponding to the dilution ratios of 1, 2, 4, 8 and 16 were 36%, 24%, 18%, 8%, and 7%, respectively, which were significantly higher than those of the control group, whose apoptosis rate was 3.5%. Neutralizing antibody could effectively reduce the cytotoxic effect of Ad-ephrinA1-caspase-3-T on EphA2 positive breast cancer cells.
conclusionsThe Ad-ephrinA1-caspase-3-T has a targeted cytotoxic effect on breast cancer cells
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