ArticleTranslational cancer research2019
Pretreatment platelet to lymphocyte ratio is predictive of overall survival in metastatic pancreatic ductal adenocarcinoma.
Article in Translational cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Review
- Serum hsa-miR-22-3p, hsa-miR-885-5p, Lipase-to-Amylase Ratio, C-Reactive Protein, CA19-9, and Neutrophil-to-Lymphocyte Ratio as Prognostic Factors in Advanced Pancreatic Ductal Adenocarcinoma.Current issues in molecular biology · 2025Article
- NLR and Platelet Dynamics: Simple, Cost-effective Biomarkers for Stratifying Severity in Acute Pancreatitis.Medical journal of the Islamic Republic of Iran · 2025Article
- Cytokines and Pancreatic Ductal Adenocarcinoma: Exploring Their Relationship with Molecular Subtypes and Prognosis.International journal of molecular sciences · 2024Article
- Article
- Liquid biopsy approach to pancreatic cancer.World journal of gastrointestinal oncology · 2021Review
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Authors and funding
6 authors.
Funding
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Abstract
backgroundThis study aimed to investigate whether the pretreatment platelet to lymphocyte ratio (PLR) is a significant prognostic factor in metastatic pancreatic ductal adenocarcinoma (PDAC).
methodsA total of 134 histologically confirmed PDAC patients were included in our retrospective study. The data included treatment regimens, Karnofsky Performance Status (KPS), and PLR. Kaplan-Meier curves and univariate and multivariate Cox proportional hazards regression analyses were applied to identify the prognostic factors associated with overall survival (OS).
resultsWe used the receiver operating characteristic (ROC) curve to set the cut-off value of the PLR. For the Kaplan-Meier analysis, the median overall survival in PDAC patients with a PLR of 123 or less was 19.7 months, whereas the values in those with a PLR greater than 123 was 13.7 months (P=0.014). PLR was a significant prognostic marker in the multivariate Cox model [hazard ratio (HR) =1.721, 95% CI: 1.162-2.550, P=0.007].
conclusionsThe PLR pretreatment had potential as prognostic indicator in patients with metastatic PDAC.
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