Evidence map›Paper›PMID 35116666›Full record

ArticleTranslational cancer research2021

Resveratrol affects the migration and apoptosis of monocytes by blocking HMGB1/NF-κB pathway.

Yuwei Zhang, Qiaoliang Dong, Chan Liu, Yingfei Zhu, Xueli Qin, Zihan Qi, Xi Zhang, Hongmei Guo, Weixiang Li, Meng Liu and 2 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Yuwei ZhangDepartment of International Medical, Second Xiangya Hospital, Central South University, Changsha, China.
Qiaoliang DongDepartment of International Medical, Second Xiangya Hospital, Central South University, Changsha, China.
Chan LiuDepartment of International Medical, Second Xiangya Hospital, Central South University, Changsha, China.
Yingfei ZhuDepartment of International Medical, Second Xiangya Hospital, Central South University, Changsha, China.
Xueli QinDepartment of International Medical, Second Xiangya Hospital, Central South University, Changsha, China.
Zihan QiDepartment of International Medical, Second Xiangya Hospital, Central South University, Changsha, China.
Xi ZhangDepartment of International Medical, Second Xiangya Hospital, Central South University, Changsha, China.
Hongmei GuoDepartment of International Medical, Second Xiangya Hospital, Central South University, Changsha, China.
Weixiang LiDepartment of International Medical, Second Xiangya Hospital, Central South University, Changsha, China.
Meng LiuDepartment of International Medical, Second Xiangya Hospital, Central South University, Changsha, China.
Lin GanDepartment of International Medical, Second Xiangya Hospital, Central South University, Changsha, China.
Hong LiuDepartment of International Medical, Second Xiangya Hospital, Central South University, Changsha, China.
Central South University · CNSecond Xiangya Hospital of Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic inflammation is now recognized as a causal factor of aging. Resveratrol is a non-flavonoid compound that widely exists in plant species, exerting anti-inflammatory effects in vitro and in animal models. The chemotaxis of inflammatory cells and secretion of cytokines are key characters in inflammation response.

methodsThe effects of lipopolysaccharide (LPS) and high mobility group box-1 (HMGB1) chromosomal on the migration, inflammatory response, and apoptosis of monocytes were detected. THP-1 cells were used to study the effects of resveratrol treatment on LPS- and HMGB-induced monocytes. We aimed to investigate the effect of Resveratrol on monocyte migration and the expression of a special cytokine named HMGB1 in THP-1 cells.

resultsResveratrol obviously inhibited THP-1 migration induced by LPS. LPS increased the expression of HMGB1 and its release in THP-1 cells, which were both decreased by resveratrol. Resveratrol inhibited the activity of NF-κB-p65 and the translocation of NF-κB-p65 from nucleus to cytoplasm induced by LPS. In addition, Resveratrol increased LPS and HMGB1-inhibited monocyte apoptosis. Resveratrol inhibited the LPS-induced HMGB1 secretion and its activation through NF-κB pathway. The THP-1 migration induced by LPS was inhibited by resveratrol.

conclusionsResveratrol may inhibit monocyte migration and induce apoptosis by blocking downstream HMGB1/NF-κB/MCP-1 signaling pathways, thereby reducing systemic inflammation.

Indexed as

aginghigh mobility group box-1 (HMGB1)lipopolysaccharide (LPS)monocyteResveratrol

Identifiers

PMID35116666
PMCPMC8797930
OpenAlexW3187089086

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.