Evidence map›Paper›PMID 35116630›Full record

ArticleTranslational cancer research2021

Hypopharynx reconstruction for primary hypopharyngeal carcinoma: a retrospective study and literature review.

Yu Heng, Duo Zhang, Xiaoke Zhu, Liang Zhou, Ming Zhang, Kenan Li, Lei Tao

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yu Heng *Department of Otolaryngology, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Duo Zhang *Department of Otolaryngology, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Xiaoke Zhu *Department of Otolaryngology, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Liang ZhouDepartment of Otolaryngology, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Ming ZhangDepartment of Otolaryngology, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Kenan LiDepartment of Otolaryngology, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Lei TaoDepartment of Otolaryngology, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Eye & ENT Hospital of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe study aims to retrospectively evaluate disparate reconstructive choices for defects in patients with primary hypopharyngeal carcinoma undergoing tumor resection.

methodsOne hundred and twenty-five patients of primary hypopharyngeal carcinamo conducted with hypopharynx reconstruction for restoring the defects causing by tumor ablation from 2003 to 2016 at Eye & ENT Hospital of Fudan University were reviewed. Most of them were treated with the following three techniques (n=115): gastric pull-up (GPU), the pedicled pectoralis major myocutaneous flap (PMMF) and the radial forearm free flap (RFFF). GPU was used for those with cervical esophagus invasion requiring esophageal resection in our institution. We focus on the postoperative complication morbidity, function of deglutition 1 month after hospital discharge and disease-free survival (DFS) outcomes.

resultsOne month after operation, 56 of 65 (86.2%) achieved solid or semisolid diet with normal swallowing function for GPU, 8 of 12 (66.7%) for RFFF and 20 of 33 (60.6%) for PMMF respectively. Postoperative complications occured in 15 (23.1%), 8 (66.7%), 16 (48.5%) for GPU, RFFF and PMMF respectively, including flap/anastomotic necrsis, pharyngeal fistula, wound infection (both recipient and donor sites), pulmonary and cardiovascular complications.

conclusionsGPU showed satisfactory outcomes for reconstruction of patients with hypopharyngeal carcinoma requiring esophageal resection. For patients without cervical esophagus invasion and underwent partial or total pharyngectomy, both PMMF and RFFF can afford good coverage and reliable functional and survival outcome as well as postoperative complication morbidity. Moreover, the only predictive factor for incidence of postoperative complication was extent of surgery, as total hypopharyngectomy was more likely to develop complications after surgery than partial hypopharyngectomy.

Indexed as

functional outcomeHypopharyngeal carcinomapharyngectomyreconstructionsurvival

Identifiers

PMID35116630
PMCPMC8797281
OpenAlexW3178853595

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.