ArticleTranslational cancer research2021
Invasive adenocarcinoma manifesting as pure ground glass nodule with different size: radiological characteristics differ while prognosis remains the same.
Article in Translational cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- ACR Appropriateness Criteria® Indolent Lung Cancer.Journal of the American College of Radiology : JACR · 2026Guideline
- Development and validation of a risk prediction model for invasiveness of pure ground-glass nodules based on a systematic review and meta-analysis.BMC medical imaging · 2024Pooled it
- The infiltration risk prediction models by logistic regression for ground-glass pulmonary nodules: a systematic review and meta-analysis.Frontiers in oncology · 2024Pooled it
- [Expert Consensus on Shared Decision-making in the Diagnosis and Treatment of Ground-glass Opacity-featured Lung Adenocarcinoma].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2026Article
- Artificial intelligence-based density proportion analysis in predicting the invasiveness of neoplastic ground-glass nodules.Translational lung cancer research · 2026Article
- Gene mutation, clinical characteristics and pathology in resectable lung adenocarcinoma.World journal of surgical oncology · 2025Article
- Radiomics of Vascular Structures in Pulmonary Ground-glass Nodules: A Predictor of InvasivenessCurrent medical imaging · 2025Article
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- Artificial intelligence-measured nodule mass for determining the invasiveness of neoplastic ground glass nodules.Quantitative imaging in medicine and surgery · 2024Article
- Artificial intelligence-based graded training of pulmonary nodules for junior radiology residents and medical imaging students.BMC medical education · 2024Article
- Discrimination of invasive lung adenocarcinoma from Lung-RADS category 2 nonsolid nodules through visual assessment: a retrospective study.European radiology · 2024Article
- Histopathologic fate of resected pulmonary pure ground glass nodule: a systematic review and meta-analysis.Journal of thoracic disease · 2024Article
- Using the length of pleural tag to predetermine pleural invasion by lung adenocarcinomas.Frontiers in oncology · 2024Article
- A nomogram based on CT intratumoral and peritumoral radiomics features preoperatively predicts poorly differentiated invasive pulmonary adenocarcinoma manifesting as subsolid or solid lesions: a double-center study.Frontiers in oncology · 2024Article
- Comparison of radiological and pathological tumor sizes in resected non-small cell lung cancer.General thoracic and cardiovascular surgery · 2023Article
- Correlations between iodine uptake, invasive CT features and pleural invasion in adenocarcinomas with pleural contact.Scientific reports · 2023Article
- A Nomogram Based on Consolidation Tumor Ratio Combined with Solid or Micropapillary Patterns for Postoperative Recurrence in Pathological Stage IA Lung Adenocarcinoma.Diagnostics (Basel, Switzerland) · 2023Article
- Radiomic and quantitative-semantic models of low-dose computed tomography for predicting the poorly differentiated invasive non-mucinous pulmonary adenocarcinoma.La Radiologia medica · 2023Article
- Clinicopathological characteristics and prognosis of young patients aged ≤45 years old with non-small cell lung cancer.Open medicine (Warsaw, Poland) · 2023Article
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5 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundInvasive adenocarcinoma (IA) manifesting as pure ground-glass nodule is rare and not been well studied. Meanwhile, tumor size is considered as a predictor of invasiveness in lung adenocarcinoma. The present study aimed to investigate the radiological and pathological characteristics as well as prognosis of IA manifesting as pure ground-glass nodule with different sizes.
methodsPatients with solitary pure ground glass nodule (GGN) who underwent resection and were pathologically diagnosed as IA between July 2013 and July 2015 were included. Nodules were divided into four groups according to size: A, B, C, and D, corresponding to "≤1 cm," "1-2 cm," "2-3 cm," and ">3 cm," respectively. The correlations and differences in radiological and pathological characteristics as well as prognosis among these groups were analyzed.
resultsThe amounts of nodules in groups A, B, C, and D are 17, 148, 78, and 30, respectively. The average diameter of these 273 nodules is 1.9 (1.5-2.4) cm. A large tumor is likely to have low computed tomography (CT) value (P<0.001), irregular shape (P=0.001), spiculation appearance (P<0.001) and exhibit pleural indentation (P<0.001) and air bronchogram (P<0.001). The proportion of lepidic predominant adenocarcinoma (LPA) (n=239, 87.5%) is much higher than that of other subtypes (n=34, 12.5%). Currently, there is no case with lymphatic, pleural, or vessel invasion and lymph node involvement, and none died of recurrence or metastasis within 5 years after resection.
conclusionsFor IA manifesting as pure ground-glass nodule, size is correlated to invasiveness, and large tumors tend to have lower CT value, an irregular shape, lobulation and spiculation appearance and exhibit pleural indentation and air bronchogram. Nevertheless, the prognosis is excellent with 100% 5-year disease-free survival regardless of the size and pathological subtype.
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