Evidence map›Paper›PMID 35116455›Full record

ArticleTranslational cancer research2021

Dan Xue, Hongguang Lin, Lan Lin, Qiongying Wei, Sheng Yang, Xiangqi Chen

Open access · diamondAbstract read
In one paragraph

Article in Translational cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 37 citations in OpenAlex.

  1. Genetic insights into lung squamous cell carcinoma: howTranslational cancer research · 2026
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  17. Titin as a potential novel therapeutic target in colorectal cancer.Journal of cellular and molecular medicine · 2023
    Article
  18. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Dan Xue *Department of Respiratory Medicine, Fujian Medical University Union Hospital, Fuzhou, China.
Hongguang Lin *Department of Respiratory Medicine, Fujian Medical University Union Hospital, Fuzhou, China.
Lan LinDepartment of Respiratory Medicine, Fujian Medical University Union Hospital, Fuzhou, China.
Qiongying WeiDepartment of Respiratory Medicine, Fujian Medical University Union Hospital, Fuzhou, China.
Sheng YangDepartment of Oncology, Fujian Medical University Union Hospital, Fuzhou, China.
Xiangqi ChenDepartment of Respiratory Medicine, Fujian Medical University Union Hospital, Fuzhou, China.
Fujian Medical University · CNUnion Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChemotherapy is the preferred treatment in many types of cancer including lung cancer. However, most of patients resist chemotherapy resulting in disease progressive and recurrence. Titin (

methodsClinical information and related somatic mutation profiles were obtained from The Cancer Genome Atlas (TCGA) database and analyzed by R-Studio using R-package. Overall survival (OS) curve and the association between gene mutation and clinical features were determined by GraphPad 6.0 software.

resultsAvailable data including 563 lung adenocarcinoma (LUAD) and 505 LUSC subjects were included in this study. Among all patients, 205 out of 563 LUAD and 326 out of 505 LUSC patients displayed

conclusionsCollectively,

Indexed as

chemotherapy responsegene mutationLung adenocarcinoma (LUAD)lung squamous carcinoma (LUSC)titin (TTN)tumor protein 53 (TP53)

Identifiers

PMID35116455
PMCPMC8798240
OpenAlexW3145162608

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.