ArticleTranslational cancer research2021
Determining the effect of ellagic acid on the proliferation and migration of pancreatic cancer cell lines.
Article in Translational cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Evaluation of the anticancer effects of ellagic acid and cisplatin in cisplatin-sensitive and -resistant MDA-MB-231 breast cancer cells.Medical oncology (Northwood, London, England) · 2026Article
- Ellagic acid is associated with reduced pancreatic carcinogenesis and modulation of the IL-6/STAT3 pathway.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2026Article
- Anticancer Drug Discovery from Natural Compounds Targeting PI3K/AKT/mTOR Signaling Pathway.Current medicinal chemistry · 2025Review
- Exploring the Potential of Ellagic Acid in Gastrointestinal Cancer Prevention: Recent Advances and Future Directions.Oncology and therapy · 2024Review
- Anti-tumor Effects of Polyphenols via Targeting Cancer Driving Signaling Pathways: A Review.Indian journal of clinical biochemistry : IJCB · 2024Review
- Bioactive Compounds from Plant Origin as Natural Antimicrobial Agents for the Treatment of Wound Infections.International journal of molecular sciences · 2024Review
- Berries vs. Disease: Revenge of the Phytochemicals.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Phytochemical analysis and anticancer effect ofFrontiers in pharmacology · 2024Article
- Ellagic Acid Prevents α-Synuclein Spread and Mitigates Toxicity by Enhancing Autophagic Flux in an Animal Model of Parkinson's Disease.Nutrients · 2023Article
- A comprehensive review on Ellagic acid in breast cancer treatment: From cellular effects to molecular mechanisms of action.Food science & nutrition · 2023Review
- Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence.Biomolecules · 2023Review
- Ellagic acid inhibits mitochondrial fission protein Drp-1 and cell proliferation in cancer.Molecular and cellular biochemistry · 2023Article
- Correlation of gene expression profiles to identify pancreatic cancer cell lines that best model primary human tumors.Translational cancer research · 2023Article
- Identification of Genes Associated with Liver Metastasis in Pancreatic Cancer Reveals PCSK6 as a Crucial Mediator.Cancers · 2022Article
- Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEllagic acid is a natural dietary compound found in several berries and fruits. It inhibits fibrosis, inflammation and carcinogenesis. We tried to find out what role ellagic acid plays in pancreatic cancer to see if it can be used as an adjuvant for chemotherapy.
methodsThree pancreatic cancer cell lines, PANC-1, AsPC-1, and MIA PaCA-2, were used. Cell growth was measured by MTT assay. Activities of caspase-3 and caspase-8, and caspase-9 were evaluated to determine the apoptosis pathway. Epithelial to mesenchymal transition was identified through mRNA expression of associated genes, which were transforming growth factor-beta, matrix metalloproteinase-2 and matrix metalloproteinase-9. Quantitative real time PCR was used to verify mRNA expression. To determine the effect on migration, transwell system was used.
resultsEllagic acid inhibits pancreatic cancer cell growth by stimulating apoptosis. Apoptosis induced by ellagic acid in pancreatic cancer cells, is mediated by the activation of caspase-3 and caspase-9, and not caspase-8. Ellagic acid also suppresses migration via the inhibition of epithelial mesenchymal transition (EMT) in pancreatic cancer cells. Ellagic acid decreased the expression levels of transforming growth factor-beta, matrix metalloproteinase-2 and matrix metalloproteinase-9, while it increased that of E-cadherin.
conclusionsThese findings suggest that ellagic acid is useful in pancreatic cancer treatment.
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