ArticleTranslational cancer research2021
Novel long noncoding RNA (lncRNA) panel as biomarkers for prognosis in lung squamous cell carcinoma via competitive endogenous RNA (ceRNA) network analysis.
Article in Translational cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Article
- Long non-coding RNA PRSS23-AS1 as ceRNA promotes breast cancer progression by regulating EMT via miR-3176 /YBX1 axis.Cancer gene therapy · 2025Article
- [Application Research of Serum miR-4646-5p, miR-3654 Combined with Traditional Lung Cancer Tumor Markers in the Diagnosis of Lung Cancer in Xuanwei, Yunnan Province].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2024Article
- Recent Advances in Extracellular Vesicles in Amyotrophic Lateral Sclerosis and Emergent Perspectives.Cells · 2023Review
- Exploration of novel biomarkers in Alzheimer's disease based on four diagnostic models.Frontiers in aging neuroscience · 2023Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe recently discovered competitive endogenous RNA (ceRNA) mechanism is considered to be actively involved in the regulation of gene expression. Such process may play a significant role in the development and evolvement of cancer. This study further explores the connection between the ceRNA mechanism and the lung squamous cell carcinoma prognosis.
methodsWe started with obtaining the RNA-seq [including long noncoding RNA (lncRNA), mRNA and microRNA (miRNA)] data of lung squamous cell carcinoma from The Cancer Genome Atlas (TCGA), and then analyzed the regulation of ceRNA network in lung squamous cell carcinoma. Bioinformatics tools based on R script were deployed.
resultsFirstly, we found that three miRNAs, including hsa-miR-2278, hsa-miR-3176 and hsa-miR-3654 formed the core of ceRNA network of lung squamous cell carcinoma. Moreover, after unsupervised training of the ceRNA network, three miRNAs were closely correlated in the network. In detail, AL590226, AL090044 and LINC01352 could interact with miR-2278; AL360219 and AC092071 could interact with miR-3654; AC010976 could interact with miR-3176. The above six lncRNAs altogether, could be used as a biomarker panel to predict the prognosis of lung squamous cell carcinoma.
conclusionsOur study suggests that these six lncRNAs may be potential diagnostic and prognostic biomarkers of lung squamous cell carcinoma, which could potentially benefit the patients in the future.
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