ArticleTranslational cancer research2021
Circulating tumor cells and neutrophil-lymphocyte ratio are predictive markers for metastatic colorectal cancer patients.
Article in Translational cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic value of the neutrophil-to-lymphocyte ratio in patients with colorectal cancer undergoing chemotherapy: a systematic review and meta-analysis.Frontiers in oncology · 2026Pooled it
- IL-6 promotes metastasis and EMT of non-small cell lung cancer cells by up-regulating FGL1 via STAT3 pathway.Translational cancer research · 2025Article
- Redefining cancer care: harnessing circulating tumor cells' potential for improved diagnosis and prognosis.Cancer cell international · 2025Review
- Advances and potentials in platelet-circulating tumor cell crosstalk.American journal of cancer research · 2025Review
- Alteration of the immunophenotype and cytokine profiles in patients affected by neuroendocrine neoplasms.Endocrine · 2024Article
- Circulating tumor cells in colorectal cancer - a review of detection methods and clinical relevance.Contemporary oncology (Poznan, Poland) · 2023Review
- Potential impact of platelet-to-lymphocyte ratio on prognosis in patients with colorectal cancer: A systematic review and meta-analysis.Frontiers in surgery · 2023Review
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12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMore accurate predictive factors for colorectal cancer (CRC) are urgently needed. This study aimed to assess the potential prognostic roles of circulating tumor cells (CTCs), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) in CRC patients.
methodsBetween 2014 and 2017, 118 CRC patients newly diagnosed at the Affiliated Zhongshan Hospital of Dalian University were retrospectively analyzed, including 72 (61%) patients that underwent radical resection (resectable CRC) and 46 (39%) advanced patients with metastatic CRC (mCRC). The CellSearch System was used to detect CTCs, and Spearman's correlation analyses tested the correlations between CTC counts and both NLR and PLR. Statistical analyses were performed using the Kaplan-Meier method, log-rank tests, and Cox proportional hazards models.
resultsOf the resectable cohort, 24% were positive for CTCs. Of the advanced cohort, 49% were positive for CTCs. The presence of CTCs was associated with advanced age (≥63 years old; P=0.037), a high PLR value (P=0.008), and a high NLR value (P=0.034). Additionally, baseline NLR [hazard ratio (HR) =0.423; 95% confidence intervals (CI), 0.223-0.803; P=0.008], PLR (HR =0.513; 95% CI, 0.276-0.954; P=0.035), and CTC counts (HR =2.155; 95% CI, 1.152-4.032; P=0.016) were significantly associated with progression-free survival (PFS) in a univariate analysis of mCRC patients that received chemotherapy. Multivariate analysis further showed that NLR (P=0.044) and CTCs (P=0.047) were independent prognostic factors for mCRC patients.
conclusionsThis study provided evidence that NLR and CTC counts could serve as robust prognostic factors for patients with mCRC.
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