Evidence map›Paper›PMID 35116093›Full record

ArticleOxidative medicine and cellular longevity2022

Interaction between TRPML1 and p62 in Regulating Autophagosome-Lysosome Fusion and Impeding Neuroaxonal Dystrophy in Alzheimer's Disease.

Lu Zhang, Yu Fang, Xuan Cheng, Yajun Lian, Hongliang Xu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Lu ZhangDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.ORCID https://orcid.org/0000-0003-2940-0131
Yu FangDepartment of ICU, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Xuan ChengDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Yajun LianDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Hongliang XuDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
First Affiliated Hospital of Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The loss of transient receptor potential mucolipin 1 (TRPML1), an endosomal and lysosomal Ca

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAnimalsAutophagosomesBrain-Derived Neurotrophic FactorCell Line, TumorDisease Models, AnimalDyneinsHumansLysosomesMaleMiceMice, Inbred C57BLMice, TransgenicNeuroaxonal DystrophiesNeuronsAmyloid beta-Peptidesamyloid beta-protein (1-42)Brain-Derived Neurotrophic FactorDyneinsMCOLN1 protein, humanPeptide FragmentsRNA, Small InterferingSequestosome-1 ProteinSQSTM1 protein, humanTransient Receptor Potential Channels

Identifiers

PMID35116093
PMCPMC8807035
OpenAlexW4210485210

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.