Evidence map›Paper›PMID 35116022›Full record

ArticleFrontiers in immunology2021

CD8

Congling Qiu, Chanchan Xiao, Zhigang Wang, Guodong Zhu, Lipeng Mao, Xiongfei Chen, Lijuan Gao, Jieping Deng, Jun Su, Huanxing Su and 9 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Deciphering Depigmentation: Mouse Models for Vitiligo Research.The Journal of investigative dermatology · 2025
    Review
  5. Article
  6. Review
  7. Review
  8. Characterizing HLA-A2-restricted CD8Frontiers in immunology · 2025
    Article
  9. Article
  10. The molecular mechanisms of CD8Frontiers in immunology · 2024
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. CD8Frontiers in immunology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 4 countries.

Congling QiuDepartment of Neurology, Affiliated Huaqiao Hospital, Jinan University, Guangzhou, China.
Chanchan XiaoDepartment of Microbiology and Immunology, Institute of Geriatric Immunology, School of Medicine, Jinan University, Guangzhou, China.
Zhigang WangDepartment of Neurology, Affiliated Huaqiao Hospital, Jinan University, Guangzhou, China.
Guodong ZhuGuangdong-Hong Kong-Macau Great Bay Area Geroscience Joint Laboratory, Department of Microbiology and Immunology, Jinan University, Guangzhou, China.
Lipeng MaoDepartment of Microbiology and Immunology, Institute of Geriatric Immunology, School of Medicine, Jinan University, Guangzhou, China.
Xiongfei ChenDepartment of Primary Public Health, Guangzhou Center for Disease Control and Prevention, Guangzhou, China.
Lijuan GaoDepartment of Microbiology and Immunology, Institute of Geriatric Immunology, School of Medicine, Jinan University, Guangzhou, China.
Jieping DengDepartment of Microbiology and Immunology, Institute of Geriatric Immunology, School of Medicine, Jinan University, Guangzhou, China.
Jun SuDepartment of Neurology, Affiliated Huaqiao Hospital, Jinan University, Guangzhou, China.
Huanxing SuGuangdong-Hong Kong-Macau Great Bay Area Geroscience Joint Laboratory, Department of Microbiology and Immunology, Jinan University, Guangzhou, China.
Evandro Fei FangGuangdong-Hong Kong-Macau Great Bay Area Geroscience Joint Laboratory, Department of Microbiology and Immunology, Jinan University, Guangzhou, China.
Zhang-Jin ZhangGuangdong-Hong Kong-Macau Great Bay Area Geroscience Joint Laboratory, Department of Microbiology and Immunology, Jinan University, Guangzhou, China.
Jikai ZhangDepartment of Biological Products and Materia Medica, Institute of Biologics and Pharmaceuticals Research, Guangzhou, China.
Caojun XieDepartment of Primary Public Health, Guangzhou Center for Disease Control and Prevention, Guangzhou, China.
Jun YuanDepartment of Primary Public Health, Guangzhou Center for Disease Control and Prevention, Guangzhou, China.
Oscar Junhong LuoGuangdong-Hong Kong-Macau Great Bay Area Geroscience Joint Laboratory, Department of Microbiology and Immunology, Jinan University, Guangzhou, China.
Li An HuangDepartment of Neurology, Affiliated Huaqiao Hospital, Jinan University, Guangzhou, China.
Pengcheng WangDepartment of Microbiology and Immunology, Institute of Geriatric Immunology, School of Medicine, Jinan University, Guangzhou, China.
Guobing ChenDepartment of Neurology, Affiliated Huaqiao Hospital, Jinan University, Guangzhou, China.
Jinan University · CNGuangzhou Center for Disease Control and Prevention · CNAkershus University Hospital · NOChinese University of Hong Kong · CNGuangdong Institute of Biological Products and Drugs · CNSouth China University of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We identified SARS-CoV-2 specific antigen epitopes by HLA-A2 binding affinity analysis and characterized their ability to activate T cells. As the pandemic continues, variations in SARS-CoV-2 virus strains have been found in many countries. In this study, we directly assess the immune response to SARS-CoV-2 epitope variants. We first predicted potential HLA-A*02:01-restricted CD8

Indexed as

AdultAgedAmino Acid SequenceAntigenic VariationAntigen PresentationCD8-Positive T-LymphocytesCOVID-19Epitopes, T-LymphocyteFemaleHLA-A2 AntigenHumansImmune EvasionLymphocyte ActivationMaleMiddle AgedMolecular Docking SimulationEpitopes, T-LymphocyteHLA-A2 AntigenSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2antigen presentation deficiencyCD8+ T-cell epitopeSARS-CoV-2spike proteinvariations

Identifiers

PMID35116022
PMCPMC8804355
OpenAlexW4205739794

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.