Efficacy and Safety of Oral Acetaminophen for Premature Infants With Patent Ductus Arteriosus: A Meta-Analysis.

Xie Zi-Yun, Zhang Ruo-Lin, Xia Yue-Wei, Bo Tao

Open access · goldAbstract readReview

In one paragraph

Review in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it

0cells of the map it votes in

6citing papers in PubMed

1.2field-weighted citation impact, top 25% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

Comparison of two targeted rescue treatments after the first week of expectant managment for very preterm infants with hemodynamically significant patent ductus arteriosus: a prospective study.Italian journal of pediatrics · 2026
Trial
A Pathophysiological Approach for Early Detection and Prevention of AKI in the NICU.American journal of perinatology · 2026
Review
Nutrition of the preterm infant with persistent ductus arteriosus: existing evidence and practical implications.Pediatric research · 2026
Review
Maternal Analgesic Exposure and Fetal Ductal Constriction: A Prospective Cohort Study in Late Pregnancy.Birth defects research · 2026
Article
Effectiveness of oralWorld journal of orthopedics · 2025
Article
Increased Total Serum Bilirubin Level Post-Ibuprofen Use Is Inversely Correlated with Neonates' Body Weight.Children (Basel, Switzerland) · 2022
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Xie Zi-YunDepartment of Pediatrics, Division of Neonatology, The Third Xiangya Hospital, Central South University, Changsha, China.

Zhang Ruo-LinDepartment of Neonatology, Nanshan Maternal and Child Health Care Hospital of Shengzhen, Shenzhen, China.

Xia Yue-WeiDepartment of Neonatology, Changsha Maternal and Child Health Care Hospital, Changsha, China.

Bo TaoDepartment of Pediatrics, Division of Neonatology, The Third Xiangya Hospital, Central South University, Changsha, China.

Central South University · CNChangsha Hospital for Maternal and Child Health Care · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

meta analysisoral acetaminophenpatent ductus arteriosuspremature infantsrandomized controlled trial

Identifiers

PMID35115919

DOI10.3389/fphar.2021.696417

PMCPMC8804357

OpenAlexW4205653523

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.