Evidence map›Paper›PMID 35115776›Full record

ArticleInternational journal of nanomedicine2022

Egr1/HSP70 Promoter-Driven Activation of Gene Expression for Synergistic Anti-Hepatoma Using PEI-MZF Nanoparticles and Radiation.

Jia Zhang, Min Dong, Yan Feng, Dongsheng Zhang, Mei Lin, Chenyan Yuan, Hongbo Li, Ling Wang, Hao Zhang, Chen Liang

Abstract read
In one paragraph

Article in International journal of nanomedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jia ZhangNanjing Medical University Affiliated Cancer Hospital & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, Jiangsu, People's Republic of China.
Min DongNanjing Medical University Affiliated Cancer Hospital & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, Jiangsu, People's Republic of China.
Yan FengNanjing Medical University Affiliated Cancer Hospital & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, Jiangsu, People's Republic of China.
Dongsheng ZhangImaging and Nuclear Medicine, Southeast University, Nanjing, Jiangsu, People's Republic of China.
Mei LinImaging and Nuclear Medicine, Southeast University, Nanjing, Jiangsu, People's Republic of China.
Chenyan YuanImaging and Nuclear Medicine, Southeast University, Nanjing, Jiangsu, People's Republic of China.
Hongbo LiImaging and Nuclear Medicine, Southeast University, Nanjing, Jiangsu, People's Republic of China.
Ling WangImaging and Nuclear Medicine, Southeast University, Nanjing, Jiangsu, People's Republic of China.
Hao ZhangImaging and Nuclear Medicine, Southeast University, Nanjing, Jiangsu, People's Republic of China.
Chen LiangImaging and Nuclear Medicine, Southeast University, Nanjing, Jiangsu, People's Republic of China.ORCID 0000-0002-8210-0819

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSpatially restricted gene expression circumvents the gene expression and gene vector problem by enabling localized amplification. The objective of this study is to construct a spatially restricted gene expression for liver cancer therapy based upon the MFH-absorbing properties of PEI- Mn

methodsMn

resultsThe Mn

conclusionThe novel site-directed heat/radiation-inducible expression system based upon the hyperthermia (by MFH) and radiation possessed superior antitumor effect in vivo and in vitro.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsNanoparticlesAnimalsCell Line, TumorEarly Growth Response Protein 1Gene ExpressionHEK293 CellsHumansMicePolyethyleneimineThymidine KinaseTransfectionEarly Growth Response Protein 1EGR1 protein, humanEgr1 protein, mousePolyethyleneimineThymidine Kinasedual sensitivemagnetic nano vectormagnet-induced heatingradiation

Identifiers

PMID35115776
PMCPMC8801369

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.