ArticleNature neuroscience2022
Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines.
Open access · hybridAbstract read
In one paragraph
Article in Nature neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 1 pooled it
17.0field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
105 citing papers in PubMed, 1 synthesis or guideline pooled it, 148 citations in OpenAlex.
- Gene expression profiles in sporadic ALS fibroblasts define disease subtypes and the metabolic effects of the investigational drug EH301.Human molecular genetics · 2022Pooled it
- An alternative splicing modulator decreases mutant HTT and improves the molecular fingerprint in Huntington's disease patient neurons.Nature communications · 2022Trial
- Therapeutic frontiers in ALS: iPSC-based drug discovery, cell therapy, and gene therapy-Advances through 2026.Regenerative therapy · 2026Review
- Modeling human neurodegeneration with iPSCs: opportunities, limitations, and the challenge of aging.The Journal of clinical investigation · 2026Review
- Insertion or deletion variants in TAF15 exon 15 are genetic factors impacting the prognosis of amyotrophic lateral sclerosis in a Japanese cohort.European journal of human genetics : EJHG · 2026Article
- Convergent TBK1 loss of function drives gasdermin E dependent pyroptosis and motor neuron degeneration across ALS genotypes.Cell death and differentiation · 2026Article
- Transcriptomic Changes Elicited by Semaglutide in Human Ventricular Tissue Support Cell Survival and Lipid Metabolism.Circulation. Heart failure · 2026Article
- Fatty acid amide hydrolase inhibition for treatment of amyotrophic lateral sclerosis.JCI insight · 2026Article
- Genetic contributions to mitochondrial dysfunction in amyotrophic lateral sclerosis etiology.HGG advances · 2026Article
- Strategic Amyotrophic Lateral Sclerosis Australia-Systems Genomics Consortium (SALSA-SGC): cohort profile.BMJ open · 2026Article
- Arrayed dual-gRNA CRISPR screening platform forMolecular therapy. Advances · 2026Article
- Sex-Specific Genetic Architecture of ALS: Evidence of a Female Protective Effect?Annals of neurology · 2026Article
- Decomposing heterogeneity in disease progression speeds and pathways.NPJ digital medicine · 2026Article
- Predictive Cellular Signatures from Live Human Motor Neurons Distinguish TDP-43 ALS and Enable ALS Subtype Stratification.bioRxiv : the preprint server for biology · 2026Article
- Neuronal Cell-Cycle Re-entry Defines Divergent Outcomes Through Replication-Dependent DNA Damage in ALS.bioRxiv : the preprint server for biology · 2026Article
- Repeat expansions inbioRxiv : the preprint server for biology · 2026Article
- Wild-typemedRxiv : the preprint server for health sciences · 2026Article
- Review
- Identification of molecular and clinical ALS subgroups based on TDP-43 loss of function molecular markers from population-based patient-derived iPS motor neurons.bioRxiv : the preprint server for biology · 2026Article
- Frag'n'Flow: automated workflow for large-scale quantitative proteomics in high performance computing environments.BMC bioinformatics · 2026Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
101 authors at 16 institutions in 1 country.
Emily G BaxiBrain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Terri ThompsonOn Point Scientific Inc., San Diego, CA, USA.
Jonathan LiDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Julia A KayeCenter for Systems and Therapeutics and the Taube/Koret Center for Neurodegenerative Disease, Gladstone Institutes and the Departments of Neurology and Physiology, University of California, San Francisco, San Francisco, CA, USA.
Ryan G LimUCI MIND, University of California, Irvine, CA, USA.ORCID http://orcid.org/0000-0001-6388-5158
Jie WuDepartment of Biological Chemistry, University of California, Irvine, CA, USA.
Divya RamamoorthyDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-9438-0419
Leandro LimaCenter for Systems and Therapeutics and the Taube/Koret Center for Neurodegenerative Disease, Gladstone Institutes and the Departments of Neurology and Physiology, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-5313-9485
Vineet VaibhavAdvanced Clinical Biosystems Research Institute, The Barbra Streisand Heart Center, The Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Andrea MatlockAdvanced Clinical Biosystems Research Institute, The Barbra Streisand Heart Center, The Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Aaron FrankCedars-Sinai Biomanufacturing Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Alyssa N CoyneBrain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-3658-5325
Barry LandinComputational Biology Center, IBM T.J. Watson Research Center, Yorktown Heights, NY, USA.
Loren OrnelasCedars-Sinai Biomanufacturing Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Elizabeth MosmillerDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sara ThrowerDepartment of Neurology, Healey Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
S Michelle FarrTechnome LLC, Herndon, VA, USA.
Lindsey PantherCedars-Sinai Biomanufacturing Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Emilda GomezCedars-Sinai Biomanufacturing Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Erick GalvezCedars-Sinai Biomanufacturing Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Daniel PerezCedars-Sinai Biomanufacturing Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Imara MeepeCedars-Sinai Biomanufacturing Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Susan LeiCedars-Sinai Biomanufacturing Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Berhan MandefroThe Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Hannah TrostThe Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Louis PinedoCedars-Sinai Biomanufacturing Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-4473-3006
Maria G BanuelosThe Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Chunyan LiuCedars-Sinai Biomanufacturing Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Ruby MoranCedars-Sinai Biomanufacturing Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Veronica GarciaThe Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Michael WorkmanThe Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Richie HoThe Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-1496-4436
Stacia WymanCenter for Systems and Therapeutics and the Taube/Koret Center for Neurodegenerative Disease, Gladstone Institutes and the Departments of Neurology and Physiology, University of California, San Francisco, San Francisco, CA, USA.
Jennifer RoggenbuckZofia Consulting, Reston, VA, USA.
Matthew B HarmsDepartment of Neurology and Genetics, Ohio State University Wexner Medical Center, Columbus, OH, USA.
Jennifer StocksdaleDepartment of Psychiatry and Human Behavior and Sue and Bill Gross Stem Cell Center, University of California, Irvine, CA, USA.
Ricardo MiramontesUCI MIND, University of California, Irvine, CA, USA.
Keona WangDepartment of Psychiatry and Human Behavior and Sue and Bill Gross Stem Cell Center, University of California, Irvine, CA, USA.
Vidya VenkatramanAdvanced Clinical Biosystems Research Institute, The Barbra Streisand Heart Center, The Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Ronald HolewenskiAdvanced Clinical Biosystems Research Institute, The Barbra Streisand Heart Center, The Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Niveda SundararamanAdvanced Clinical Biosystems Research Institute, The Barbra Streisand Heart Center, The Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Rakhi PandeyAdvanced Clinical Biosystems Research Institute, The Barbra Streisand Heart Center, The Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Danica-Mae ManaloAdvanced Clinical Biosystems Research Institute, The Barbra Streisand Heart Center, The Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Aneesh DondeDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Nhan HuynhDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Miriam AdamDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Brook T WassieDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Edward VertudesCenter for Systems and Therapeutics and the Taube/Koret Center for Neurodegenerative Disease, Gladstone Institutes and the Departments of Neurology and Physiology, University of California, San Francisco, San Francisco, CA, USA.
Naufa AmiraniCenter for Systems and Therapeutics and the Taube/Koret Center for Neurodegenerative Disease, Gladstone Institutes and the Departments of Neurology and Physiology, University of California, San Francisco, San Francisco, CA, USA.
Krishna RajaCenter for Systems and Therapeutics and the Taube/Koret Center for Neurodegenerative Disease, Gladstone Institutes and the Departments of Neurology and Physiology, University of California, San Francisco, San Francisco, CA, USA.
Reuben ThomasCenter for Systems and Therapeutics and the Taube/Koret Center for Neurodegenerative Disease, Gladstone Institutes and the Departments of Neurology and Physiology, University of California, San Francisco, San Francisco, CA, USA.
Lindsey HayesDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Alex LenailDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Aianna CerezoDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sarah LuppinoDepartment of Neurology, Healey Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Alanna FarrarDepartment of Neurology, Healey Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Lindsay PothierDepartment of Neurology, Healey Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2377-1778
Carolyn PrinaDepartment of Neurology and Genetics, Ohio State University Wexner Medical Center, Columbus, OH, USA.
Todd MorganTexas Neurology, Dallas, TX, USA.
Arish JamilDepartment of Neurology, Emory University, Atlanta, GA, USA.
Sarah HeintzmanDepartment of Neurology and Genetics, Ohio State University Wexner Medical Center, Columbus, OH, USA.
Jennifer Jockel-BalsarottiDepartment of Neurology, Washington University, St. Louis, MO, USA.
Elizabeth KaranjaDepartment of Neurology, Washington University, St. Louis, MO, USA.
Jesse MarkwayDepartment of Neurology, Washington University, St. Louis, MO, USA.
Molly McCallumDepartment of Neurology, Washington University, St. Louis, MO, USA.
Ben JoslinDepartment of Neurology, Northwestern University, Chicago, IL, USA.
Deniz AlibazogluDepartment of Neurology, Northwestern University, Chicago, IL, USA.
Stephen KolbDepartment of Neurology and Genetics, Ohio State University Wexner Medical Center, Columbus, OH, USA.ORCID http://orcid.org/0000-0002-8503-8459
Senda Ajroud-DrissDepartment of Neurology, Northwestern University, Chicago, IL, USA.
Robert BalohThe Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-0100-8376
Daragh HeitzmanTexas Neurology, Dallas, TX, USA.
Tim MillerDepartment of Neurology, Washington University, St. Louis, MO, USA.
Jonathan D GlassDepartment of Neurology, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-3295-4971
Natasha Leanna Patel-MurrayDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Hong YuDepartment of Neurology, Healey Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Ervin SinaniDepartment of Neurology, Healey Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Prasha VigneswaranDepartment of Neurology, Healey Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Alexander V ShermanDepartment of Neurology, Healey Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Omar AhmadDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Promit RoyDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jay C BeaversMicrosoft Research, Microsoft Corporation, Redmond, WA, USA.
Steven ZeilerDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
John W KrakauerDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Carla AgurtoComputational Biology Center, IBM T.J. Watson Research Center, Yorktown Heights, NY, USA.ORCID http://orcid.org/0000-0002-0617-4488
Guillermo CecchiComputational Biology Center, IBM T.J. Watson Research Center, Yorktown Heights, NY, USA.ORCID http://orcid.org/0000-0003-1013-8348
Mary BellardMicrosoft University Relations, Microsoft Corporation, Redmond, WA, USA.
Yogindra RaghavDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-1285-6397
Karen SachsDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Tobias EhrenbergerDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Elizabeth BruceMicrosoft University Relations, Microsoft Corporation, Redmond, WA, USA.
Merit E CudkowiczDepartment of Neurology, Healey Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7075-1681
Nicholas MaragakisDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-7311-9614
Raquel NorelComputational Biology Center, IBM T.J. Watson Research Center, Yorktown Heights, NY, USA.ORCID http://orcid.org/0000-0001-7737-4172
Jennifer E Van EykAdvanced Clinical Biosystems Research Institute, The Barbra Streisand Heart Center, The Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-9050-148X
Steven FinkbeinerCenter for Systems and Therapeutics and the Taube/Koret Center for Neurodegenerative Disease, Gladstone Institutes and the Departments of Neurology and Physiology, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-3480-394X
James BerryDepartment of Neurology, Healey Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Dhruv SareenCedars-Sinai Biomanufacturing Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-0898-9656
Leslie M ThompsonUCI MIND, University of California, Irvine, CA, USA.ORCID http://orcid.org/0000-0003-4573-9514
Ernest FraenkelDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-9249-8181
Clive N SvendsenCedars-Sinai Biomanufacturing Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-8696-3446
Jeffrey D RothsteinBrain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA. jrothstein@jhmi.edu.ORCID http://orcid.org/0000-0003-2001-8470
Cedars-Sinai Medical Center · USMassachusetts Institute of Technology · USHarvard University · USJohns Hopkins University · USGladstone Institutes · USUniversity of California, Irvine · USWashington University in St. Louis · USIBM (United States) · USThe Ohio State University Wexner Medical Center · USMicrosoft (United States) · USNorthwestern University · USEmory University · USTexas Neurology · USABS Consulting (United States) · USAllen Institute for Brain Science · USFirst Point Scientific · US
Funding
Validation of r(G4C2)exp-binding small molecules in vivo and c9FTD/ALS biomarker developmentP01NS099114 · NINDS · UNIVERSITY OF FLORIDA · PI DISNEY, MATTHEW D, PETRUCELLI, LEONARD · 2017 to 2021
$6.5MGraduate Training in Computational and Systems BiologyT32GM087237 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BURGE, CHRISTOPHER B · 2009 to 2023
$4.6MNuclear pore complex quality control in ALS/FTDR01NS122236 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LUSK, CHARLES PATRICK, ROTHSTEIN, JEFFREY D · 2021 to 2025
$4.0MNuclear Pore Complex and as a Contributor to Tau Associated DementiaRF1AG062171 · NIA · JOHNS HOPKINS UNIVERSITY · PI PETRUCELLI, LEONARD, ROTHSTEIN, JEFFREY D · 2019 to 2019
$3.8MNucleocytoplasmic transport and nuclear pore disruption in ALS/FTDR01NS094239 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LLOYD, THOMAS E., ROTHSTEIN, JEFFREY D · 2016 to 2020
$3.4MALS/FTD mutant C9orf72-induced genetic and nuclear pathology in iPS cell modelsR01NS085207 · NINDS · JOHNS HOPKINS UNIVERSITY · PI ROTHSTEIN, JEFFREY D, SATTLER, RITA · 2013 to 2017
$1.8MNew hiPSC tools for astroglial-focused approaches to ALSU24NS078736 · NINDS · JOHNS HOPKINS UNIVERSITY · PI EGGAN, KEVIN C, HENDERSON, CHRISTOPHER · 2012 to 2013
$1.6MFG-nucleoporins and nuclear transport disruption in C9ORF72-ALS/FTDK08NS104273 · NINDS · JOHNS HOPKINS UNIVERSITY · PI HAYES, LINDSEY RENAE · 2017 to 2021
$999kNIA NIH HHS RF1 AG062171NIGMS NIH HHS T32 GM087237NINDS NIH HHS K08 NS104273NINDS NIH HHS P01 NS099114NINDS NIH HHS R01 NS085207NINDS NIH HHS R01 NS094239NINDS NIH HHS R01 NS122236NINDS NIH HHS U24 NS078736
Abstract
Answer ALS is a biological and clinical resource of patient-derived, induced pluripotent stem (iPS) cell lines, multi-omic data derived from iPS neurons and longitudinal clinical and smartphone data from over 1,000 patients with ALS. This resource provides population-level biological and clinical data that may be employed to identify clinical-molecular-biochemical subtypes of amyotrophic lateral sclerosis (ALS). A unique smartphone-based system was employed to collect deep clinical data, including fine motor activity, speech, breathing and linguistics/cognition. The iPS spinal neurons were blood derived from each patient and these cells underwent multi-omic analytics including whole-genome sequencing, RNA transcriptomics, ATAC-sequencing and proteomics. The intent of these data is for the generation of integrated clinical and biological signatures using bioinformatics, statistics and computational biology to establish patterns that may lead to a better understanding of the underlying mechanisms of disease, including subgroup identification. A web portal for open-source sharing of all data was developed for widespread community-based data analytics.
Indexed as
Amyotrophic Lateral SclerosisInduced Pluripotent Stem CellsCell LineHumansMotor Neurons
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