ArticleNature genetics2022
Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project.
Erratum issuedAbstract read
In one paragraph
Article in Nature genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 331 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
331citing papers in PubMed, 5 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
331 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- The impact of gut microbiome on intrahepatic cholestasis of pregnancy-systematic literature review.Frontiers in medicine · 2026Pooled it
- Gut microbiome and atrial fibrillation: mechanistic insights metabolites and comorbidities. Systematic review.Gut microbes · 2025Pooled it
- Multi-Omics Analyses Reveal Relationships Between Gut Microbiota and Frailty.Brain and behavior · 2025Pooled it
- Immunocytes Mediate the Effects of Gut Microbiome on Inflammatory Bowel Disease: Insights From a Mendelian Randomization Study.Mediators of inflammation · 2025Pooled it
- Causal Relationships Between Gut Microbiota, Inflammatory Cells/Proteins, and Subarachnoid Hemorrhage: A Multi-omics Bidirectional Mendelian Randomization Study and Meta-analysis.Molecular neurobiology · 2024Pooled it
- A narrative review of the epidemiological and mechanistic associations between ABO blood groups and diseases: focusing on cardiovascular diseases, cancers, diabetes, malaria, COVID-19 and rheumatic diseases.Annals of medicine · 2026Review
- Article
- Causal relationships between the gut microbiota, immune cells, and diabetic kidney disease: a Mendelian randomization and mediation analysis.Renal failure · 2026Article
- Global and local trajectories of infant gut microbiota development in Bangladesh across the COVID-19 pandemic.mSystems · 2026Article
- Two-sample Mendelian randomization study of gut microbiota and inflammatory proteins: Predictive, preventive, and personalized treatment for migraine.Neural regeneration research · 2026Article
- Toward A Pre-disease State-centered New Paradigm in Multi-omics Research.Genomics, proteomics & bioinformatics · 2026Article
- Microbiota-Immune Crosstalk in Pneumonia and Acute Lung Injury: Mechanisms, Evidence, and Therapeutic Opportunities.Microorganisms · 2026Review
- Potential role of Akkermansia massiliensis in multiple sclerosis protection by the FcRL3 gene.Genes and immunity · 2026Article
- Gut Microbiota and Ischemic Stroke: From Pre-Stroke Dysbiosis and Acute-Phase Changes to Therapeutic Applications.Brain and behavior · 2026Review
- Dissecting the Ecological Structure of Health and Disease in the Global Gut Microbiome.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Causal relationship between gut microbiota, circulating inflammatory proteins, and IgA nephropathy: two-sample and mediated Mendelian randomization analysis.International urology and nephrology · 2026Article
- Integrating host-microbiome multi-omics with machine learning: methods, benchmarks, and translational applications.Science China. Life sciences · 2026Review
- Effects of Gut Microbiome and Metabolic Pathways on Obesity: A Two-Sample Mendelian Randomization and Case-Control Study.Iranian journal of biotechnology · 2026Article
- Article
- Integrating gene-microbiome interactions and single-cell transcriptomics reveals therapeutic strategies for aortic aneurysm.iScience · 2026Article
271 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
22 authors.
Esteban A Lopera-Maya *Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Alexander Kurilshikov *Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0003-2541-5627
Adriaan van der Graaf *Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0002-8898-8484
Shixian Hu *Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Sergio Andreu-SánchezDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0002-3503-9971
Lianmin ChenDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0003-0660-3518
Arnau Vich VilaDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0003-4691-5583
Ranko GacesaDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0003-2119-0539
Trishla SinhaDepartment of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Valerie CollijDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Marjiolein A Y KlaassenDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Laura A BolteDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0001-6036-0831
Milla F Brandao GoisDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0001-7918-2481
Pieter B T NeerincxDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Morris A SwertzDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0002-0979-3401
LifeLines Cohort Study
Hermie J M HarmsenDepartment of Medical Microbiology and Infection Prevention, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0003-2725-6148
Cisca WijmengaDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0002-5635-1614
Jingyuan FuDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Rinse K WeersmaDepartment of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Alexandra ZhernakovaDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. sasha.zhernakova@gmail.com.ORCID http://orcid.org/0000-0002-4574-0841
Serena SannaDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. serena.sanna@irgb.cnr.it.ORCID http://orcid.org/0000-0002-3768-1749
Funding
No grant is acknowledged in the PubMed record.
Abstract
Host genetics are known to influence the gut microbiome, yet their role remains poorly understood. To robustly characterize these effects, we performed a genome-wide association study of 207 taxa and 205 pathways representing microbial composition and function in 7,738 participants of the Dutch Microbiome Project. Two robust, study-wide significant (P < 1.89 × 10
Indexed as
Bacterial Physiological PhenomenaGastrointestinal MicrobiomeGenetic VariationHost Microbial InteractionsABO Blood-Group SystemBifidobacteriumDietFucosyltransferasesGalactoside 2-alpha-L-fucosyltransferaseGastrointestinal TractGenome, HumanGenome-Wide Association StudyHumansLactaseMetabolic Networks and PathwaysMetagenomeABO Blood-Group SystemFucosyltransferasesGalactoside 2-alpha-L-fucosyltransferaseLactaseSodium Chloride, DietaryTriglycerides
Identifiers
PMID
35115690What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.