Evidence map›Paper›PMID 35115643›Full record

ArticleScientific reports2022

Hard polymeric porous microneedles on stretchable substrate for transdermal drug delivery.

Aydin Sadeqi, Gita Kiaee, Wenxin Zeng, Hojatollah Rezaei Nejad, Sameer Sonkusale

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 82 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Aydin SadeqiNano Lab, Advanced Technology Laboratory, Tufts University, 200 Boston Avenue, Medford, MA, 02155, USA.
Gita KiaeeNano Lab, Advanced Technology Laboratory, Tufts University, 200 Boston Avenue, Medford, MA, 02155, USA.
Wenxin ZengNano Lab, Advanced Technology Laboratory, Tufts University, 200 Boston Avenue, Medford, MA, 02155, USA.
Hojatollah Rezaei NejadNano Lab, Advanced Technology Laboratory, Tufts University, 200 Boston Avenue, Medford, MA, 02155, USA. hojat.rezaei@theheropatch.com.
Sameer SonkusaleNano Lab, Advanced Technology Laboratory, Tufts University, 200 Boston Avenue, Medford, MA, 02155, USA. sameer.sonkusale@tufts.edu.
Tufts University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microneedles offer a convenient transdermal delivery route with potential for long term sustained release of drugs. However current microneedle technologies may not have the mechanical properties for reliable and stable penetration (e.g. hydrogel microneedles). Moreover, it is also challenging to realize microneedle arrays with large size and high flexibility. There is also an inherent upper limit to the amount and kind of drugs that can be loaded in the microneedles. In this paper, we present a new class of polymeric porous microneedles made from biocompatible and photo-curable resin that address these challenges. The microneedles are unique in their ability to load solid drug formulation in concentrated form. We demonstrate the loading and release of solid formulation of anesthetic and non-steroidal anti-inflammatory drugs, namely Lidocaine and Ibuprofen. Paper also demonstrates realization of large area (6 × 20 cm

Indexed as

Drug CarriersNeedlesAdministration, CutaneousAnesthetics, LocalAnimalsAnti-Inflammatory Agents, Non-SteroidalDrug CompoundingDrug Delivery SystemsDrug LiberationHardnessIbuprofenLidocaineMiniaturizationPolymersPorositySkin AbsorptionAnesthetics, LocalAnti-Inflammatory Agents, Non-SteroidalDrug CarriersIbuprofenLidocainePolymers

Identifiers

PMID35115643
PMCPMC8813900
OpenAlexW4210525570

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.