Evidence map›Paper›PMID 35115550›Full record

ArticleScientific reports2022

Energy homeostasis genes modify the association between serum concentrations of IGF-1 and IGFBP-3 and breast cancer risk.

Rocío Rodríguez-Valentín, Gabriela Torres-Mejía, Louis Martínez-Matsushita, Angélica Angeles-Llerenas, Liliana Gómez-Flores-Ramos, Roger K Wolff, Kathy B Baumgartner, Lisa M Hines, Elad Ziv, Lourdes Flores-Luna and 3 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Rocío Rodríguez-ValentínCenter for Population Health Research, National Institute of Public Health, 62100, Cuernavaca, Morelos, Mexico.
Gabriela Torres-MejíaCenter for Population Health Research, National Institute of Public Health, 62100, Cuernavaca, Morelos, Mexico. gtorres@insp.mx.
Louis Martínez-MatsushitaDepartment of Geriatrics, Hospital General Regional 251, 52148, Metepec, Estado de Mexico, Mexico.
Angélica Angeles-LlerenasCenter for Population Health Research, National Institute of Public Health, 62100, Cuernavaca, Morelos, Mexico.
Liliana Gómez-Flores-RamosCátedras CONACYT-Center for Population Health Research, National Institute of Public Health, 62100, Cuernavaca, Morelos, Mexico.
Roger K WolffDepartment of Medicine, University of Utah, Salt Lake City, UT, 84108, USA.
Kathy B BaumgartnerDepartment of Epidemiology and Population Health, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, 40202, USA.
Lisa M HinesDepartment of Biology, University of Colorado Colorado Springs, Colorado Springs, CO, 80918, USA.
Elad ZivDepartment of Medicine, Institute of Human Genetics, University of California San Francisco, San Francisco, CA, 94158, USA.
Lourdes Flores-LunaCenter for Population Health Research, National Institute of Public Health, 62100, Cuernavaca, Morelos, Mexico.
Luisa Ma Sánchez-ZamoranoCenter for Population Health Research, National Institute of Public Health, 62100, Cuernavaca, Morelos, Mexico.
Eduardo Ortiz-PanozoCenter for Population Health Research, National Institute of Public Health, 62100, Cuernavaca, Morelos, Mexico.
Martha L SlatteryDepartment of Medicine, University of Utah, Salt Lake City, UT, 84108, USA.
Instituto Nacional de Salud Pública · MXUniversity of Utah · USUniversity of California, San Francisco · USUniversity of Colorado Colorado Springs · USUniversity of Louisville · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer is a multifactorial disease in which the interplay among multiple risk factors remains unclear. Energy homeostasis genes play an important role in carcinogenesis and their interactions with the serum concentrations of IGF-1 and IGFBP-3 on the risk of breast cancer have not yet been investigated. The aim of this study was to assess the modifying effect of the genetic variation in some energy homeostasis genes on the association of serum concentrations of IGF-1 and IGFBP-3 with breast cancer risk. We analyzed 78 SNPs from 10 energy homeostasis genes in premenopausal women from the 4-Corner's Breast Cancer Study (61 cases and 155 controls) and the Mexico Breast Cancer Study (204 cases and 282 controls). After data harmonization, 71 SNPs in HWE were included for interaction analysis. Two SNPs in two genes (MBOAT rs13272159 and NPY rs16131) showed an effect modification on the association between IGF-1 serum concentration and breast cancer risk (P

Indexed as

Polymorphism, Single NucleotideAdultBiomarkers, TumorBreast NeoplasmsCase-Control StudiesEnergy MetabolismFemaleGenetic Association StudiesHumansInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IMiddle AgedPredictive Value of TestsPremenopauseRisk AssessmentRisk FactorsBiomarkers, TumorIGF1 protein, humanIGFBP3 protein, humanInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor I

Identifiers

PMID35115550
PMCPMC8813998
OpenAlexW4210686671

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.