ArticleNature communications2022
A role for ColV plasmids in the evolution of pathogenic Escherichia coli ST58.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed, 88 citations in OpenAlex.
- Article
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- Genomic investigation of the vancomycin-resistant Enterococcus faecium in a tertiary hospital in China.Antimicrobial resistance and infection control · 2026Article
- Genomic Diversity and Virulence Potential of High-Priority Critically Important Antimicrobial-ResistantPathogens (Basel, Switzerland) · 2026Article
- Cross-species and cross-border spread of aph(3')-ia-mediated neomycin resistance in Escherichia coli from animals: a genomic perspective.The Journal of antimicrobial chemotherapy · 2026Article
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- Whole Genome Sequencing Reveals Genetic Variability ofAntibiotics (Basel, Switzerland) · 2026Article
- Genomic survey uncovers the emergence of a multidrug-resistant dominant lineage in Proteus mirabilis populations.npj antimicrobials and resistance · 2026Article
- A One Health comparative genomic assessment of antimicrobial-resistantApplied and environmental microbiology · 2026Article
- Insights Into Global Antimicrobial Resistance Dynamics Through the Sequencing of Enteric Bacteria From US International Travelers.The Journal of infectious diseases · 2026Article
- Genomic epidemiology and plasmid characterization of antimicrobial resistance and virulence in cattleMicrobiology spectrum · 2026Article
- Coexistence of aInfection and drug resistance · 2026Article
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- Characterization ofFrontiers in veterinary science · 2026Article
- Avian PathogenicVeterinary sciences · 2025Review
- Challenges and considerations for whole-genome-based antimicrobial resistance plasmid investigations.Antimicrobial agents and chemotherapy · 2025Review
- Convergence of plasmid-driven virulence and antibiotic resistance in Escherichia coli.Nature communications · 2025Article
- ESBL-producingOne health (Amsterdam, Netherlands) · 2025Article
4 more citing papers are in PubMed but not listed here.
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Authors and funding
18 authors at 8 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Escherichia coli ST58 has recently emerged as a globally disseminated uropathogen that often progresses to sepsis. Unlike most pandemic extra-intestinal pathogenic E. coli (ExPEC), which belong to pathogenic phylogroup B2, ST58 belongs to the environmental/commensal phylogroup B1. Here, we present a pan-genomic analysis of a global collection of 752 ST58 isolates from diverse sources. We identify a large ST58 sub-lineage characterized by near ubiquitous carriage of ColV plasmids, which carry genes encoding virulence factors, and by a distinct accessory genome including genes typical of the Yersiniabactin High Pathogenicity Island. This sub-lineage includes three-quarters of all ExPEC sequences in our study and has a broad host range, although poultry and porcine sources predominate. By contrast, strains isolated from cattle often lack ColV plasmids. Our data indicate that ColV plasmid acquisition contributed to the divergence of the major ST58 sub-lineage, and different sub-lineages inhabit poultry, swine and cattle.
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