Evidence map›Paper›PMID 35115530›Full record

ArticleNature communications2022

Constructing neural network models from brain data reveals representational transformations linked to adaptive behavior.

Takuya Ito, Guangyu Robert Yang, Patryk Laurent, Douglas H Schultz, Michael W Cole

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 62 citations in OpenAlex.

  1. Frontoparietal Hub Connectivity Integrates Information from Multiple Sources.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  2. Article
  3. Article
  4. Task context is broadly encoded in the human brain.bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Takuya ItoCenter for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ, USA. taku.ito1@gmail.com.ORCID 0000-0002-2060-4608
Guangyu Robert YangDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Patryk LaurentIndependent Researcher, San Diego, CA, USA.
Douglas H SchultzCenter for Brain, Biology and Behavior, University of Nebraska-Lincoln, Lincoln, NE, USA.
Michael W ColeCenter for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ, USA.
Rutgers, The State University of New Jersey · USFilm Independent · USMassachusetts Institute of Technology · USUniversity of Nebraska–Lincoln · US

Funding

Brain Network Mechanisms of Aging-Related Cognitive DeclineR01AG055556 · NIA · RUTGERS THE STATE UNIV OF NJ NEWARK · PI COLE, MICHAEL WILLIAM · 2017 to 2022
$2.3M
Brain Network Mechanisms of Instructed LearningR01MH109520 · NIMH · RUTGERS THE STATE UNIV OF NJ NEWARK · PI COLE, MICHAEL WILLIAM · 2016 to 2020
$2.0M
Network Mechanisms of Flexible Cognitive ControlR00MH096801 · NIMH · RUTGERS THE STATE UNIV OF NJ NEWARK · PI COLE, MICHAEL WILLIAM · 2014 to 2016
$747k
NIA NIH HHS R01 AG055556NIMH NIH HHS R00 MH096801NIMH NIH HHS R01 MH109520
6 · The paper itself

Abstract

The human ability to adaptively implement a wide variety of tasks is thought to emerge from the dynamic transformation of cognitive information. We hypothesized that these transformations are implemented via conjunctive activations in "conjunction hubs"-brain regions that selectively integrate sensory, cognitive, and motor activations. We used recent advances in using functional connectivity to map the flow of activity between brain regions to construct a task-performing neural network model from fMRI data during a cognitive control task. We verified the importance of conjunction hubs in cognitive computations by simulating neural activity flow over this empirically-estimated functional connectivity model. These empirically-specified simulations produced above-chance task performance (motor responses) by integrating sensory and task rule activations in conjunction hubs. These findings reveal the role of conjunction hubs in supporting flexible cognitive computations, while demonstrating the feasibility of using empirically-estimated neural network models to gain insight into cognitive computations in the human brain.

Indexed as

Neural Networks, ComputerAdaptation, PsychologicalAdultAlgorithmsBrainBrain MappingCognitionCohort StudiesFemaleHumansMagnetic Resonance ImagingMaleNerve NetNeural PathwaysPsychomotor PerformanceYoung Adult

Identifiers

PMID35115530
PMCPMC8814166
OpenAlexW4210494776

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.