Evidence map›Paper›PMID 35115380›Full record

ArticleGenes & development2022

BMAL1 drives muscle repair through control of hypoxic NAD

Pei Zhu, Noah X Hamlish, Abhishek Vijay Thakkar, Adam W T Steffeck, Emily J Rendleman, Nabiha H Khan, Nathan J Waldeck, Andrew W DeVilbiss, Misty S Martin-Sandoval, Thomas P Mathews and 2 more

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 42 citations in OpenAlex.

  1. Review
  2. Article
  3. New insights into the skeletal muscle circadian clock in ruminants.Journal of animal science and biotechnology · 2026
    Review
  4. Article
  5. Article
  6. Circadian clock and cancer.Military Medical Research · 2026
    Review
  7. Review
  8. Article
  9. NADH dehydrogenase reverses dietary and clock metabolic syndrome.bioRxiv : the preprint server for biology · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Ablation of satellite cell-specific clock gene, Bmal1, alters force production, muscle damage, and repair following contractile-induced injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Pei ZhuDepartment of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Noah X HamlishDepartment of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Abhishek Vijay ThakkarDepartment of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Adam W T SteffeckDepartment of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Emily J RendlemanDepartment of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Nabiha H KhanDepartment of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Nathan J WaldeckDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Andrew W DeVilbissChildren's Research Institute, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA.ORCID 0000-0002-9739-2543
Misty S Martin-SandovalChildren's Research Institute, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA.
Thomas P MathewsChildren's Research Institute, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA.
Navdeep S ChandelDepartment of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Clara B PeekDepartment of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.ORCID 0000-0003-0873-0879
Northwestern University · USThe University of Texas Southwestern Medical Center · US

Funding

Tissue resident macrophages regulate proteostasis in the aging lungP01AG049665 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GR Scott Budinger · 2015 to 2026
$26.9M
Mitochondrial metabolism and ROS regulate cancerR35CA197532 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHANDEL, NAVDEEP S · 2016 to 2022
$6.3M
Clock Control of Muscle Glucose Metabolism and HIF ActivityR01DK123358 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Clara Bien Peek · 2020 to 2026
$2.4M
Role of HSF1 in Hematopoietic Stem Cell Maintenance and FunctionF32HL135975 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI DEVILBISS, ANDREW W · 2017 to 2019
$179k
Circadian Control of Nutrient-Sensing Pathways Through Clock-HIF Interactions in Skeletal MuscleR03DK116012 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PEEK, CLARA BIEN · 2018 to 2019
$158k
Circadian Mechanisms of Hedonic Feeding in ObesityF31DK130589 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WALDECK, NATHAN JAMES · 2021 to 2023
$126k
NCI NIH HHS R35 CA197532NHLBI NIH HHS F32 HL135975NIA NIH HHS P01 AG049665NIDDK NIH HHS F31 DK130589NIDDK NIH HHS R01 DK123358NIDDK NIH HHS R03 DK116012
6 · The paper itself

Abstract

The process of tissue regeneration occurs in a developmentally timed manner, yet the role of circadian timing is not understood. Here, we identify a role for the adult muscle stem cell (MuSC)-autonomous clock in the control of muscle regeneration following acute ischemic injury. We observed greater muscle repair capacity following injury during the active/wake period as compared with the inactive/rest period in mice, and loss of

Indexed as

ARNTL Transcription FactorsNADSatellite Cells, Skeletal MuscleAnimalsCell DifferentiationHypoxiaMiceMuscle DevelopmentMuscle, SkeletalMyoblastsARNTL Transcription FactorsBmal1 protein, mouseNADcircadian rhythmhypoxiamuscle regenerationmuscle stem cellNAD+

Identifiers

PMID35115380
PMCPMC8887128
OpenAlexW4210634935

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.