Evidence map›Paper›PMID 35115368›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2022

Short-Term Colony-Stimulating Factor 1 Receptor Inhibition-Induced Repopulation After Stroke Assessed by Longitudinal

Cristina Barca, Amanda J Kiliaan, Lydia Wachsmuth, Claudia Foray, Sven Hermann, Cornelius Faber, Michael Schäfers, Maximilian Wiesmann, Bastian Zinnhardt, Andreas H Jacobs

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Cristina BarcaEuropean Institute for Molecular Imaging, University of Münster, Münster, Germany; ahjacobs@uni-muenster.de cristina.barca@uni-muenster.de.
Amanda J KiliaanDepartment of Medical Imaging/Anatomy, Radboud University Medical Center, Radboud, The Netherlands.
Lydia WachsmuthTranslational Research Imaging Center, University Hospital Münster, Münster, Germany.
Claudia ForayEuropean Institute for Molecular Imaging, University of Münster, Münster, Germany.
Sven HermannEuropean Institute for Molecular Imaging, University of Münster, Münster, Germany.
Cornelius FaberTranslational Research Imaging Center, University Hospital Münster, Münster, Germany.
Michael SchäfersEuropean Institute for Molecular Imaging, University of Münster, Münster, Germany.
Maximilian WiesmannDepartment of Medical Imaging/Anatomy, Radboud University Medical Center, Radboud, The Netherlands.
Bastian ZinnhardtEuropean Institute for Molecular Imaging, University of Münster, Münster, Germany.
Andreas H JacobsEuropean Institute for Molecular Imaging, University of Münster, Münster, Germany; ahjacobs@uni-muenster.de cristina.barca@uni-muenster.de.
University of Münster · DERadboud University Medical Center · NLUniversity Hospital Münster · DEJohanniter-Krankenhaus Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Studies on colony-stimulating factor 1 receptor (CSF-1R) inhibition-induced microglia depletion indicated that inhibitor withdrawal allowed the renewal of the microglia compartment via repopulation and resolved the inflammatory imbalance. Therefore, we investigated for the first time (to our knowledge) the effects of microglia repopulation on inflammation and functional outcomes in an ischemic mouse model using translocator protein (TSPO)-PET/CT and MR imaging, ex vivo characterization, and behavioral tests.

Indexed as

Fluorine RadioisotopesStrokeAcetamidesAnimalsCalciumCarrier ProteinsInfarctionMacrophage Colony-Stimulating FactorMiceMice, Inbred C57BLMicrogliaOrganic ChemicalsPositron-Emission TomographyPositron Emission Tomography Computed TomographyPyrazolesPyrimidinesAcetamidesCalciumCarrier ProteinsFluorine RadioisotopesMacrophage Colony-Stimulating FactorN,N-diethyl-2-(2-(4-(2-fluoroethoxy)phenyl)-5,7-dimethylpyrazolo(1,5-a)pyrimidin-3-yl)acetamideOrganic ChemicalsPLX5622PyrazolesPyrimidinesReceptors, Granulocyte-Macrophage Colony-Stimulating Factor18F-DPA-714colony-stimulating factor 1 receptormicrogliarepopulationstroke

Identifiers

PMID35115368
PMCPMC9454465
OpenAlexW4210558813

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.