ArticleThe European respiratory journal2022
A polygenic risk score and age of diagnosis of COPD.
Article in The European respiratory journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Plasma protein signatures of adult asthma.Allergy · 2024Pooled it
- Article
- Multi-trait polygenic scores for COPD and COPD exacerbations implicate druggable proteins.JCI insight · 2026Article
- Treatment of chronic obstructive pulmonary disease: current pipeline and new opportunities.Nature reviews. Drug discovery · 2026Review
- Age-dependent Genetic Risk in Pulmonary Fibrosis Patients and Relatives.medRxiv : the preprint server for health sciences · 2026Article
- Clinical characteristics and outcomes of chronic obstructive pulmonary disease patients with family history of chronic airway disease.Annals of medicine · 2025Article
- Article
- Towards early detection and disease interception of COPD across the lifespan.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- Omic Risk Scores are Associated with COPD-related Traits Across Three Cohorts.medRxiv : the preprint server for health sciences · 2025Article
- Influence and role of polygenic risk score in the development of 32 complex diseases.Journal of global health · 2025Article
- Article
- Exploring the genetics of airflow limitation in lung function across the lifespan - a polygenic risk score study.EClinicalMedicine · 2024Article
- Screening the Best Risk Model and Susceptibility SNPs for Chronic Obstructive Pulmonary Disease (COPD) Based on Machine Learning Algorithms.International journal of chronic obstructive pulmonary disease · 2024Article
- Predicting early-onset COPD risk in adults aged 20-50 using electronic health records and machine learning.PeerJ · 2024Article
- Screening COPD-Related Biomarkers and Traditional Chinese Medicine Prediction Based on Bioinformatics and Machine Learning.International journal of chronic obstructive pulmonary disease · 2024Article
- Clinical relevance of lung function trajectory clusters in middle-aged and older adults.ERJ open research · 2024Article
- Prediction and stratification of longitudinal risk for chronic obstructive pulmonary disease across smoking behaviors.Nature communications · 2023Article
- Polygenic risk scores identify heterogeneity in asthma and chronic obstructive pulmonary disease.The Journal of allergy and clinical immunology · 2023Article
- Lung Function Trajectories and Associated Mortality among Adults with and without Airway Obstruction.American journal of respiratory and critical care medicine · 2023Article
- Revealing lncRNA Biomarkers Related to Chronic Obstructive Pulmonary Disease Based on Bioinformatics.International journal of chronic obstructive pulmonary disease · 2022Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundGenetic susceptibility may be associated with earlier onset of chronic obstructive pulmonary disease (COPD). We hypothesised that a polygenic risk score (PRS) for COPD would be associated with earlier age of diagnosis of COPD.
methodsIn 6647 non-Hispanic White (NHW) and 2464 African American (AA) participants from COPDGene, and 6812 participants from the Framingham Heart Study (FHS), we tested the relationship of the PRS and age of COPD diagnosis. Age at diagnosis was determined by: 1) self-reported age at COPD diagnosis or 2) age at visits when moderate-to-severe airflow limitation (Global Initiative for Chronic Obstructive Lung Disease (GOLD) grade 2-4) was observed on spirometry. We used Cox regression to examine the overall and time-dependent effects of the PRS on incident COPD. In the COPDGene study, we also examined the PRS's predictive value for COPD at age <50 years (COPD50) using logistic regression and area under the curve (AUC) analyses, with and without the addition of other risk factors present at early life (
resultsIn Cox models, the PRS demonstrated age-dependent associations with incident COPD, with larger effects at younger ages in both cohorts. The PRS was associated with COPD50 (OR 1.55 (95% CI 1.41-1.71) for NHW, OR 1.23 (95% CI 1.05-1.43) for AA and OR 2.47 (95% CI 2.12-2.88) for FHS participants). In COPDGene, adding the PRS to known early-life risk factors improved prediction of COPD50 in NHW (AUC 0.69
conclusionsA COPD PRS is associated with earlier age of diagnosis of COPD and retains predictive value when added to known early-life risk factors.
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