Evidence map›Paper›PMID 35115307›Full record

ArticleAJNR. American journal of neuroradiology2022

Effects of Tissue Temperature and Injury on ADC during Therapeutic Hypothermia in Newborn Hypoxic-Ischemic Encephalopathy.

C Zenobi, J L Wisnowski, B Tamrazi, A M-C Wong, R Chapman, S Blüml, T-W Wu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

C ZenobiFrom the Los Angeles County+USC Medical Center (C.Z.).ORCID 0000-0002-6901-8116
J L WisnowskiDepartments of Radiology and Pediatrics (J.L.W., B.T., S.B.).ORCID 0000-0002-4039-8362
B TamraziDepartments of Radiology and Pediatrics (J.L.W., B.T., S.B.).ORCID 0000-0003-4795-8454
A M-C WongDepartment of Medical Imaging and Intervention (A.M.-C.W.), Chang Gung Memorial Hospital, Keelung/Linkou, Taiwan.ORCID 0000-0002-7187-8350
R ChapmanDivision of Neonatology (J.L.W., R.C., T.-W.W.), Fetal and Neonatal Institute.ORCID 0000-0002-7280-9007
S BlümlDepartments of Radiology and Pediatrics (J.L.W., B.T., S.B.).ORCID 0000-0003-2124-797X
T-W WuPediatrics (S.B., T.-W.W.), Keck School of Medicine of USC, Los Angeles, California twu@chla.usc.edu.ORCID 0000-0001-5155-6189
Children's Hospital of Los Angeles · USPerinatal Institute · GBChang Gung University of Science and Technology · TWKeck Hospital of USC · USLAC+USC Medical Center · US

Funding

Validating MRS lipids as biomarkers of brain injury in neonates with hypoxic-ischemic encephalopathyK23HD099309 · NICHD · CHILDREN'S HOSPITAL OF LOS ANGELES · PI WISNOWSKI, JESSICA L · 2019 to 2023
$693k
NICHD NIH HHS K23 HD099309
6 · The paper itself

Abstract

background and purposeADC changes are useful in detecting ischemic brain injury, but mechanisms other than tissue pathology may affect the kinetic movement and diffusion of water molecules. We aimed to determine the effects of brain temperature on the corresponding ADC in infants undergoing therapeutic hypothermia. MATERIALS AND

methodsBrain temperature and ADC values in the basal ganglia, thalamus, cortical GM, and WM were analyzed during and after therapeutic hypothermia. The study cohort was categorized as having no-injury or injury. Among infants without injury, the correlation between ADC values and temperature was analyzed using the Pearson correlation. Intrasubject comparison of ADC changes during and after therapeutic hypothermia were analyzed, excluding patients who had an MR image interval of >5 days to minimize the effects of injury evolution.

resultsThirty-nine infants with hypoxic-ischemic encephalopathy were enrolled (23 no-injury; 16 injury). The median ADC was significantly lower during therapeutic hypothermia (837; interquartile range, 771-928, versus 906; interquartile range, 844-1032 ×10

conclusionsAside from brain injury, reduced tissue temperature may also contribute to diffusion restriction on MR imaging in infants undergoing therapeutic hypothermia.

Indexed as

Brain InjuriesHypothermia, InducedHypoxia-Ischemia, BrainHumansInfantInfant, NewbornMagnetic Resonance ImagingTemperature

Identifiers

PMID35115307
PMCPMC8910815
OpenAlexW4210565167

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.