SynthesisThe Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology2022
Is Helicobacter pylori Infection Associated with Celiac Disease? A Meta-analysis.
Synthesis in The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- The relationship between Helicobacter pylori severity and hematological parameters in pediatric patients with celiac disease.BMC pediatrics · 2026Observational
- The hidden link between iron deficiency and celiac disease: a clinical perspective.Frontiers in immunology · 2026Article
- Infection with Helicobacter pylori and the age at onset of coeliac disease in the "HUNT4" survey.BMC research notes · 2025Article
- Immune responses to infection and autoimmune diseases in the UK biobank.Journal of translational autoimmunity · 2025Article
- Article
- Selected Markers of Inflammation in the Saliva of Children Infected withInternational journal of molecular sciences · 2024Article
- Article
- Celiac Disease Genetics, Pathogenesis, and Standard Therapy for Japanese Patients.International journal of molecular sciences · 2023Review
- The Importance of Accurate Early Diagnosis and Eradication inAntibiotics (Basel, Switzerland) · 2022Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSome studies have reported the correlation between Helicobacter pylori and celiac disease (CD), but the results lack consistency. This meta-analysis aimed to quantify the relationship between H. pylori and CD. In addition, the study also analyzed the impact of H. pylori on the symptoms and classification of CD.
methodsStudies published up to September 1, 2020 on 3 databases - EMBASE, MEDICINE, and PubMed - were searched. The statistical data of articles which met the requirements were collated and extracted.
resultsTwenty-five papers and 141 355 participants were finally enrolled. The results showed that the H. pylori infection rate of CD patients was 0.57 times greater compared to controls (OR = 0.57, 95% CI [0.44, 0.75]), while statistical differences were also seen in the subgroups of children (OR = 0.53, 95% CI [0.33, 0.85]) and adults (OR = 0.63, 95% CI [0.49, 0.81]). Furthermore, patients having CD with H. pylori were more likely to have symptoms of abdominal pain, diarrhea, and distension (OR = 2.5, 95% CI [1.35, 4.62]) (OR = 1.56, 95% CI [1.09, 2.24]) (OR = 2.75, 95% CI [1.74, 4.35]). However, H. pylori has no effect on CD classification.
conclusionThe study confirmed that there is a correlation between H. pylori and CD, but the causality cannot be clarified. A demonstration of a causal role of H. pylori in CD in future prospective studies could have important therapeutic implications.
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